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Plant Science Today (PST)

Review Articles

Vol. 9 No. 4 (2022)

Pseudodictamnus africanus (L.) Salmaki & Siadati (Lamiaceae): Ethnomedicinal uses, phytochemistry and pharmacological properties

DOI
https://doi.org/10.14719/pst.1629
Submitted
16 December 2021
Published
14-07-2022 — Updated on 22-10-2022
Versions

Abstract

Pseudodictamnus africanus (L.) Salmaki & Siadati is a perennial herb which naturally occurs in Namibia and South Africa. Southern Africa is characterized by several indigenous medicinal plants and natural products that are widely used in traditional materia medica. However, there is dearth of information on botanical description, medicinal uses, plant parts used, preparation and dosage, active ingredients and pharmacological effects of medicinal plants like P. africanus in the public domain. Therefore, this study reviewed the medicinal uses, active bioactives and biological activities of P. africanus. A systematic review of electronic databases and pre-electronic sources with information on the botany, medicinal uses, herbal preparations, active bioactives and pharmacological effects of P. africanus was conducted. No time limit was set for the research and all literature sources aligned with the scope of the research were included. This study showed that P. africanus is used as traditional medicine for liver problems, sores, wounds, heart problems, hysteria, skin ailments, headache, insomnia, fever, typhoid fever and respiratory problems. Pharmacological research identified hispanolone, dehydrohispanolone, saponins, tannins, phenolics, flavonoids, reducing sugars, resveratrol, triterpene steroids and essential oils. The crude extracts of P. africanus and essential oils isolated from the species exhibited antibacterial, antifungal, anti-inflammatory, anti-nociceptive, immunological and sedative-hypnotic activities. More research is needed to assert the medicinal and ethnopharmacological properties of the crude extracts of P. africanus and phytochemical compounds isolated from the species, and also determine the toxicological effects of the species and its phytochemical compounds.

References

  1. Van Wyk B-E, Wink M. Medicinal Plants of the World: An Illustrated Scientific Guide to Important Medicinal Plants and Their Use. Briza Publications, Pretoria. 2017. https://doi.org/10.1079/9781786393258.0000
  2. Codd LE. The genus Ballota. Flora of S. Afr. 1985;28:48-50. https://doi.org/10.17764/jiet.1.28.2.g5367h1124v87467
  3. Siadati S, Salmaki Y, Mehrvarz SS, Heubl G, Weigned M. Untangling the generic boundaries in tribe Marrubieae (Lamiaceae: Lamioideae) using nuclear and plastid DNA sequences. Taxon. 2018;67:770-83. https://doi.org/10.12705/674.6.
  4. Siadati S, Salmaki Y, Brauchler C. Trichome morphology provides phylogenetically informative signal for generic delimitation in tribe Marrubieae (Lamiaceae). Flora. 2020;273:151720. https://doi.org/10.1016/j.flora.2020.151720
  5. Manning J. Photo guide to the wildflowers of South Africa. Briza Publications, Pretoria. 2012.
  6. Manning JC, Goldblatt P. Plants of the Greater Cape Floristic region 1: The Core Cape Flora. South African National Biodiversity Institute, Pretoria. 2012.
  7. Snijman D. 2013. Plants of the Greater Cape Floristic region 2: The extra Cape Flora. South African National Biodiversity Institute, Pretoria. 2013.
  8. Germishuizen G, Meyer NL. Plants of Southern Africa: An annotated checklist. Strelitzia 14, National Botanical Institute, Pretoria. 2003.
  9. Arnold TH, Prentice CA, Hawker LC, Snyman EE, Tomalin M,Crouch NR, Pottas-Bircher C. Medicinal and magical plants of southern Africa: An annotated checklist Strelitzia 13, National Botanical Institute, Pretoria. 2002.
  10. Van Wyk B-E, Van Oudtshoorn B, Gericke N. Medicinal Plants of South Africa. Briza Publications, Pretoria. 2013.
  11. Van Wyk B-E. 2011. The potential of South African plants in the development of new medicinal products. S Afr J Bot. 2011;77:812-29. https://doi.org/10.1016/j.sajb.2011.08.011
  12. Watt JM, Breyer-Brandwijk MG. The Medicinal and Poisonous Plants of Southern and Eastern Africa. Livingstone, London. 1962.
  13. Van Wyk B-E, Gericke N. People's plants: A Guide to Useful Plants of Southern Africa. Briza Publications, Pretoria. 2018.
  14. Van Wyk B-E. A review of Khoisan and Cape Dutch medical ethnobotany. J Ethnopharmacol. 2008;119:331-41. https://doi.org/10.1016/j.jep.2008.07.021.
  15. Welcome AK, Van Wyk B-E. An inventory and analysis of the food plants of southern Africa. S Afr J Bot. 2019;122:136-79. https://doi.org/10.1016/j.sajb.2018.11.003
  16. Raimondo D, von Staden L, Foden W, Victor JE, Helme NA, Turner RC, Kamundi DA, Manyama PA. Red List of South African plants. Strelitzia, 25. South African National Biodiversity Institute, Pretoria. 2009.
  17. Maroyi A. Ethnobotanical study of medicinal plants used by people in Nhema communal area, Zimbabwe. J Ethnopharmacol. 2011;136:347-54. https://doi.org/10.1016/j.jep.2011.05.003.
  18. Maroyi A. Traditional use of medicinal plants in south-central Zimbabwe: Review and perspectives. J Ethnobiol Ethnomed. 2013;9:31. https://doi.org/10.1186/1746-4269-9-31.
  19. Maroyi A. Use of ethnomedicinal herbs to treat and manage schistosomiasis in Zimbabwe: Past trends and future directions. In: JL Martinez, Munoz-Acevedo A, Rai M, editors., Ethnobotany: Application of Medicinal Plants, CPC Press, London. 2019, pp. 36-47.
  20. Van Wyk B-E, Wink M. Phytomedicines, herbal drugs and plant poisons. Briza Publications, Pretoria. 2015. https://doi.org/10.7208/chicago/9780226205076.001.0001
  21. Van Vuuren SF, Motlhatlego KE, Netshia V. Traditionally used polyherbals in a southern African therapeutic context. J Ethnopharmacol. 2022;288:114977. https://doi.org/10.1016/j.jep.2022.114977.
  22. Davids D, Gibson D, Johnson Q. Ethnobotanical survey of medicinal plants used to manage high blood pressure and type 2 diabetes mellitus in Bitterfontein, Western Cape Province, South Africa. J Ethnopharmacol. 2016;194:755-66. https://doi.org/10.1016/j.jep.2016.10.063
  23. Van der Walt L. Ballota africana (L.) Benth., 2004. Available from: http://pza.sanbi.org/ballota-africana, accessed on 17 November 2021.
  24. Thring TSA, Weitz FM. Medicinal plant use in the Bredasdorp/Elim region of the Southern Overberg in the Western Cape Province of South Africa. J Ethnopharmacol. 2006;103:261-75. https://doi.org/10.1016/j.jep.2005.08.013
  25. Philander LA. An ethnobotany of Western Cape Rasta bush medicine. J Ethnopharmacol. 2011;138:578-94. https://doi.org/10.1016/j.jep.2011.10.004
  26. Philander LEA, Makunga NP, Platten SJ. Local medicinal plant knowledge in South Africa preserved by apartheid. Hum Ecol. 2011;39:203-16. https://doi.org/10.1007/s10745-011-9387-x
  27. Arendse ML. Medicinal plant use in the Dwarsrivier Valley, Stellenbosch. MSc Dissertation. University of the Western Cape, Cape Town. 2013.
  28. Cock IE, van Vuuren SF. Anti-proteus activity of some South African medicinal plants: their potential for the prevention of rheumatoid arthritis. Inflammopharmacol. 2014;22:23-36. https://doi.org/10.1007/s10787-013-0179-3
  29. Nortje JM. Medicinal ethnobotany of the Kamiesberg, Namaqualand, Northern Cape province, South Africa. MSc Dissertation, University of Johannesburg, Johannesburg. 2011
  30. Nortje JM, Van Wyk B-E. Medicinal plants of the Kamiesberg, Namaqualand, South Africa. J Ethnopharmacol. 2015;171:205-22. https://doi.org/10.1016/j.jep.2015.04.049
  31. Hulley IM, Van Wyk B-E. Quantitative medicinal ethnobotany of Kannaland (western Little Karoo, South Africa): Non-homogeneity amongst villages. S Afr J Bot. 2019;122:225-65. https://doi.org/10.1016/j.sajb.2018.03.014
  32. Rosselli S, Fontana G, Bruno M. A review of the phytochemistry, traditional uses, and biological activities of the genus Ballota and Otostegia. Planta Med. 2019;85:869-910. https://doi.org/10.1055/a-0953-6165
  33. Rattray RD, Van Wyk B-E. The botanical, chemical and ethnobotanical diversity of southern African Lamiaceae. Molecules. 2021;26:3712. https://doi.org/10.3390/molecules26123712
  34. Davies-Coleman MT, Rivett DEA. Transformation of hispanolone from Ballota africana into 15,16-epoxy-9-hydroxylabda-13(16),14-diene. S Afr J Chem. 1990;43:117-19.
  35. Roberts M, Roberts S. Indigenous Healing Plants. Briza Publications, Pretoria. 2017.
  36. Cock IE, Ndlovu N, Van Vuuren SF. The use of South African botanical species for the control of blood sugar. J Ethnopharmacol. 2021;264:113234. https://doi.org/10.1016/j.jep.2020.113234
  37. Cocks ML, Wiersum KF. The significance of plant diversity to rural households in Eastern Cape province of South Africa. For Trees Livelih. 2003;13:39-58. https://doi.org/10.1080/14728028.2003.9752443
  38. Scott GA, Springfield EP, Coldrey N. A pharmacognostical study of 26 South African plant species used as traditional medicines. Pharm Biol. 2004;42:186-13. https://doi.org/10.1080/13880200490514032
  39. De Beer JJJ, Van Wyk B-E. An ethnobotanical survey of the Agter–Hantam, Northern Cape province, South Africa. S Afr J Bot. 2011;77:741-54. https://doi.org/10.1016/j.sajb.2011.03.013
  40. Lall N, Kishore N. Are plants used for skin care in South Africa fully explored? J Ethnopharmacol. 2014;153:61-84. https://doi.org/10.1016/j.jep.2014.02.021
  41. Motlhatlego KE. Evaluation of plants used in African traditional medicine for asthma and related conditions. MSc Dissertation. University of KwaZulu-Natal, Pietermaritzburg. 2014.
  42. Etsassala NGER. Detection of selective tyrosinase inhibitors from some South African plant extracts of Lamiaceae family. MSc Dissertation. University of the Western Cape, Cape Town. 2016.
  43. Van Wyk B-E. A review of African medicinal and aromatic plants. In: Neffati M, Najjaa H, Mathé A, editors., Medicinal and aromatic plants of the world: Africa volume 3. Springer, Leiden. 2017; pp. 19-60. https://doi.org/10.1007/978-94-024-1120-1_2
  44. Van Wyk B-E, Gorelik B. The history and ethnobotany of Cape herbal teas. S Afr J Bot. 2017;110:18-38. https://doi.org/10.1016/j.sajb.2016.11.011
  45. Morteza-Semnani K, Ghanbarimasir Z. A review on traditional uses, phytochemistry and pharmacological activities of the genus Ballota. J Ethnopharmacol. 2019;233:197-217. https://doi.org/10.1016/j.jep.2018.12.001.
  46. Van Wyk B-E, De Wet H, Van Heerden FR. An ethnobotanical survey of medicinal plants in the southeastern Karoo, South Africa. S Afr J Bot. 2008;74:696-704. https://doi.org/10.1016/j.sajb.2008.05.001
  47. Amabeoku GJ, Mbamalu ON, Amardien L, Mbiyi MF, Mohamed M, Motala IM, Toffar WN. Investigation of the anti-nociceptive and sedative hypnotic effects of leaf methanol extract of Ballota africana (L.) Benth. (Lamiaceae) in mice. Clin Exp Pharmacol. 2016;6:4. http://dx.doi.org/10.4172/2161-1459.C1.014
  48. Sobiecki JF. A preliminary inventory of plants used for psychoactive purposes in southern African healing traditions. Transact Royal Soc S Afr. 2002;57:1-24. https://doi.org/10.1080/00359190209520523
  49. Nzue, APMM. Use and conservation status of medicinal plants in the Cape Peninsula, Western Cape province of South Africa. Unpublished MSc thesis. University of Stellenbosch, Stellenbosch. 2009.
  50. Balogun FO, Ashafa AOT. Review of plants used in South African traditional medicine for the management and treatment of hypertension. Planta Med. 2019;85:312-34. https://doi.org/10.1055/a-0801-8771
  51. Niazi M, Yari F, Shakarami A. A review of medicinal herbs in the Lamiaceae family used to treat arterial hypertension. Entomol Appl Sci Lett. 2019;6:22-27.
  52. Stafford GI, Pedersen ME, Van Staden J, Jäger AK. Review on plants with CNS-effects used in traditional South African medicine against mental diseases. J Ethnopharmacol. 2008;119:513-37. https://doi.org/10.1016/j.jep.2008.08.010
  53. Masondo NA, Stafford GI, Aremu AO, Makunga NP. Acetylcholinesterase inhibitors from southern African plants: An overview of ethnobotanical, pharmacological potential and phytochemical research including and beyond Alzheimer's disease treatment. S Afr J Bot. 2019;120:39-64. https://doi.org/10.1016/j.sajb.2018.09.011
  54. Stafford GI, Pedersen ME, Van Staden J, Jäger AK. Review on plants with CNS-effects used in traditional South African medicine against mental diseases. J Ethnopharmacol. 2008;119:513-37. https://doi.org/10.1016/j.jep.2008.08.010
  55. Khumalo GP, Van Wyk B-E, Feng Y, Cock IE. A review of the traditional use of southern African medicinal plants for the treatment of inflammation and inflammatory pain. J Ethnopharmacol. 2022;283:114436. https://doi.org/10.1016/j.jep.2021.114436
  56. Frum Y. In vitro 5-Lipoxygenase and anti-oxidant activities of South African medicinal plants commonly used topically for skin diseases. MSc Dissertation. University of the Witwatersrand, Johannesburg. 2006. https://doi.org/10.1159/000095253
  57. Wheat NM. An ethnobotanical, phytochemical and metabolomics investigation of plants from the Paulshoek communal area, Namaqualand. PhD Thesis. University of Cape Town, Cape Town. 2013.
  58. McGaw LJ, Lall N, Meyer JJM, Eloff JN. The potential of South African plants against Mycobacterium infections. J Ethnopharmacol. 2008;119:482-500. https://doi.org/10.1016/j.jep.2008.08.022.
  59. Hutchings A, Scott AH, Lewis G, Cunningham AB. Zulu medicinal plants: An inventory. University of Natal Press, Pietermaritzburg. 1996.
  60. Cock IE, Van Vuuren SF. The traditional use of southern African medicinal plants in the treatment of viral respiratory diseases: A review of the ethnobotany and scientific evaluations. J Ethnopharmacol. 2020;262:113194. https://doi.org/10.1016/j.jep.2020.113194.
  61. Ndhlovu PT, Omotayo AO, Otang-Mbeng W, Aremu AO. Ethnobotanical review of plants used for the management and treatment of childhood diseases and well-being in South Africa. S Afr J Bot. 2021;137:197-215. https://doi.org/10.1016/j.sajb.2020.10.012
  62. Cock IE, Van Vuuren SF. The potential of selected South African plants with anti-Klebsiella activity for the treatment and prevention of Ankylosing spondylitis. Inflammopharmacol. 2015;23:21-35. https://doi.org/10.1007/s10787-014-0222-z.
  63. Frum Y, Viljoen AM. In vitro 5-lipoxygenase and antioxidant activities of South African medicinal plants commonly used topically for skin diseases. Skin Pharmacol Physiol. 2006;19:329-35. https://doi.org/10.1159/000095253
  64. Heinrich M, Appendino G, Efferth T, Fürst R, Izzo AA, Kayser O, Pezzuto JM, Viljoen A. Best practice in research: Overcoming common challenges in phytopharmacological research. J Ethnopharmacol. 2020;246:112230. https://doi.org/10.1016/j.jep.2019.112230

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