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Plant Science Today (PST)

Research Articles

Vol. 11 No. 4 (2024)

Soursop (Annona muricata L.) in Indonesia: Biological evaluation, student perspective and internet trends

DOI
https://doi.org/10.14719/pst.3035
Submitted
23 October 2023
Published
22-10-2024 — Updated on 23-10-2024
Versions

Abstract

The study provided an overview of soursop (Annona muricata L.) in Indonesia, covering taxonomy, phytochemicals, antimicrobial tests, college student perspectives, and internet trends. Taxonomy details were sourced from literature, and herbarium specimens were deposited in the herbaria. Phytochemical compounds were identified using a UV-Vis spectrophotometer, while antimicrobial activity was assessed through disc diffusion. Student perspectives were collected via questionnaires, and internet trends were tracked with Google Trends. Data on taxonomy, student perspectives, and internet trends were analyzed descriptively, while experimental data underwent Kruskal-Wallis testing. Soursop, originally from tropical America, was likely introduced to Indonesia before 1884 and is now widespread. Soursop leaf extract exhibited phenol (2554.22 mg/100g), flavonoid (5263.43 mg/100g), and tannin (1469.77 mg/100g) presence. The study demonstrated its potent antimicrobial properties at concentrations of 25%, 40%, 55%, and 70%, with a 6 mm growth inhibition zone. College students at Health Polytechnic of Denpasar identified 42 treatable diseases with soursop, with fidelity levels (FL) ranging from 2.7% to 48.65%. The highest FL was observed for gout. Leaf and fruit parts of soursop are commonly used in traditional medicine. The trend of internet searches regarding the utilization of soursop (January 2011–September 2023) peaked in January 2012 and then declined until 2023, with the majority of searches occurring in central-western Indonesia.

References

  1. Moghadamtousi SZ, Fadaeinasab M, Nikzad S, Mohan G, Ali HM, Kadir HA. Annona muricata (Annonaceae): a review of its traditional uses, isolated acetogenins and biological activities. Int J Molec Sci. 2015;16(7):15625-58. https://doi.org/10.3390/ijms160715625
  2. Mutakin M, Fauziati R, Fadhilah FN, Zuhrotun A, Amalia R, Hadisaputri YE. Pharmacological activities of soursop (Annona muricata Lin.). Molecules. 2022;27(1201):1-17. https://doi.org/10.3390/molecules27041201
  3. Tuna MR, Kepel BJ, Leman MA. Uji daya hambat ekstrak daun sirsak (Annona muricata L.) terhadap pertumbuhan Staphylococcus aureus secara in vitro, Pharmacon. 2015;4(4):65-70. https://doi.org/10.35799/pha.4.2015.10194
  4. Kalgo ZM, Amin BM, Muhammed B, Saka HK. Prevalence and risk factors for lower respiratory tract infection: a multicenter study, at Kebbi State, Nigeria. Int J Adv Health Sci Tech. 2023;3(1):60-67. https://doi.org/10.35882/ijahst.v3i1.170
  5. Linz MS, Mattappallil A, Finkel D, Parker D. Clinical impact of Staphylococcus aureus skin and soft tissue infections. Antibiotics. 2023;12(557):1-27. https://doi.org/10.3390/antibiotics12030557
  6. Bassetti M, Labate L, Melchio M, Robba C, Battaglini D, Ball L, et al. Current pharmacotherapy for methicillin-resistant Staphylococcus aureus (MRSA) pneumonia. Exp Opinion Pharm. 2022;23(3):361-75. https://doi.org/10.1080/14656566.2021.2010706
  7. Béraud G, Tubiana S, Erpelding ML, Moing VL, Chirouze C, Gorenne I, et al. Combined bacterial meningitis and infective endocarditis: when should we search for the other when either one is diagnosed? Infect Diseases Ther. 2022;11:1521-40. https://doi.org/10.1007/s40121-022-00651-7
  8. Leistner R, Hanitsch LG, Krüger R, Lindner AK, Stegemann MS, Nurjadi D. Skin infections due to panton-valentine leukocidin-producing S. Aureus. Deutsc Arzt Int. 2022;119(45):775-84. https://doi.org/10.3238/arztebl.m2022.0308
  9. Habib G, Mahmood K, Gul H, Tariq M, Ain QU, Hayat A, et al. Pathophysiology of methicillin-resistant Staphylococcus aureus superinfection in COVID-19 patients. Pathophysiology. 2022;29(3):405-13. https://doi.org/10.3390/pathophysiology29030032
  10. Nandhini P, Kumar P, Mickymaray S, Alothaim AS, Somasundaram J, Rajan M. Recent developments in methicillin-resistant Staphylococcus aureus (MRSA) treatment: a review. Antibiotics. 2022;11(606):1-21. https://doi.org/10.3390/antibiotics11050606
  11. Lázár V, Snitser O, Barkan D, Kishony R. Antibiotic combinations reduce Staphylococcus aureus clearance. Nature. 2022;610:540-46. https://doi.org/10.1038/s41586-022-05260-5
  12. Agu KC, Okolie PN. Proximate composition, phytochemical analysis and in vitro antioxidant potentials of extracts of Annona muricata (soursop). Food Sci Nutr. 2017:5(5):1029-36. https://doi.org/10.1002/fsn3.498
  13. Hasan AEZ, Julistiono H, Bermawie N, Riyanti EI, Arifni FR. Soursop leaves (Annona muricata L.) endophytic fungi anticancer activity against HeLa cells. Saudi J Bio Sci. 2022;29(103354):1-9. https://doi.org/10.1016/j.sjbs.2022.103354
  14. Wullur AC, Schaduw J, Wardhani ANK. Identifikasi alkaloid pada daun sirsak (Annona muricata L.). J Ilmiah Farm. 2012;3(2):54-56.
  15. Cornelia M, Natania K, Cahyana H, Sutiyono E. Encapsulation of soursop (Annona muricata Linn.) leaf tea extract using natural mucilage. Reaktor. 2019;19(1):26-33. https://doi.org/10.14710/reaktor.19.1.26-33
  16. Ciuperc? OT, ?ebrencu CE, Volf I. Polyphenolic content evaluation in branches of Rosa canina L. and Hippophae rhamnoides L. species. Bul Inst Polit Ia?i. 2017;63(67):49-58.
  17. Khan ZA, Siddiqui MF, Park S. Current and emerging methods of antibiotic susceptibility testing. Diagnostics. 2019;9(49):1-17. https://doi.org/10.3390/diagnostics9020049
  18. Andriamparany JN, Brinkmann K, Jeannoda V, Buerkert A. Effects of socio-economic household characteristics on traditional knowledge and usage of wild yams and medicinal plants in the Mahafaly region of south-western Madagascar. J Ethnobiol Ethnomed. 2014;10(82):1-20. https://doi.org/10.1186/1746-4269-10-82
  19. Koesriharti. Annona muricata L. In: Verheij EWM, Coronel RE, editors. Plant Resources of South-East Asia no 2: Edible Fruits and Nuts. Bogor: PROSEA Foundation; 1991. p. 75-78.
  20. Damayanto IPGP, Muhaimin M. Notes on Chimonobambusa quadrangularis (Franceschi) Makino (Poaceae: Bambusoideae) as an invasive alien plant species in Indonesia. Floribunda. 2017;5(7):253-57. https://doi.org/10.32556/floribunda.v5i7.2017.201
  21. Ariati SR, Astuti RS, Supriyatna I, Yuswandi AY, Setiawan A, Saftaningsih D, et al. An alphabetical list of plant species cultivated in the Bogor Botanic Gardens. Bogor: Indonesian Institute of Sciences, Center for Plant Conservation, Bogor Botanic Gardens; 2019.
  22. Wulandari L, Dewi MKC, Kristiningrum N, Siswanti RAYN. Determination of total phenolic content and NIR-chemometrics classification model of queen and local varieties of soursop (Annona muricata L.) leaf powder. Indon J Chem. 2020;20(3):520-29. https://doi.org/10.22146/ijc.43051
  23. Laohavisit A, Wakatake T, Ishihama N, Mulvey H, Takizawa K, Suzuki T, et al. Quinone perception in plants via leucine-rich-repeat receptor-like kinases. Nature. 2020;587(7832):92-97. https://doi.org/10.1038/s41586-020-2655-4
  24. Goel S, Parihar PS, Meshram V. Plant-derived quinones as a source of antibacterial and anticancer agents. In: Singh J, Meshram V, Gupta M, editors. Bioactive Natural Products in Drug Discovery. Singapore: Springer; 2020. p. 245-79.
  25. Nguyen MT, Nguyen VT, Minh LV, Trieu LH, Cang MH, Bui LB, et al. Determination of the phytochemical screening, total polyphenols, flavonoids content and antioxidant activity of soursop leaves (Annona muricata Linn.). In: IOP Conf Ser Mat Sci Eng; 2020.736(062011):1-6. https://doi.org/10.1088/1757-899X/736/6/062011
  26. Agu KC, Okolie NP, Eze I, Anionye JC, Falodun A. Phytochemical analysis, toxicity profile, and hemomodulatory properties of Annona muricata (soursop). Egypt J Haemat. 2017;42(1):36-44. https://doi.org/10.4103/1110-1067.206431
  27. Muthu S, Durairaj B. Evaluation of antioxidant and free radical scavenging activity of Annona muricata. Europ J Exp Biol. 2015;5(3):39-45.
  28. Pérez-Burillo S, Giménez R, Rufián-Henares JA, Pastoriza S. Effect of brewing time and temperature on antioxidant capacity and phenols of white tea: relationship with sensory properties. Food Chem. 2018;248:111-18. https://doi.org/10.1016/j.foodchem.2017.12.056
  29. Guzmán-Maldonado SH, López-Manzano MJ, Madera-Santana TJ, Núñez-Colín CA, Grijalva-Verdugo CP, Villa-Lerma AG, et al. Nutritional characterization of Moringa oleifera leaves, seeds, husks and flowers from two regions of Mexico. Agr Colomb. 2020;38(2):287-97. https://doi.org/10.15446/agron.colomb.v38n2.82644
  30. Rarassari MA, Maftuch HN. Phytochemicals and antibacterial activities of soursop leaf (Annona muricata) against Edwadsiella tarda (in vitro). J Life Sci Biomed. 2016;6(1):6-9.
  31. Makuasa DAA, Ningsih P. The analysis of total flavonoid levels in young leaves and old soursop leaves (Annona muricata L.) using UV-vis sepctrofotometry methods. J App Sci Eng Tech Educ. 2020;2(1):11-17. https://doi.org/10.35877/454RI.asci2133
  32. Febriani D, Mulyanti D, Rismawati E. Karakterisasi simplisia dan ekstrak etanol daun sirsak (Annona muricata Linn.). Pr Farm Spesia. 2015;1(2):475-80. https://doi.org/10.29313/.v0i0
  33. Hermawan GP, Hendrawan L. Ekstrak daun sirsak (Annona muricata L) menggunakan pelarut etanol. J Tekn Kimia Indust. 2013;2(2):111-15.
  34. Yuliantari NWA, Widarta IWR, Permana IDGM. Pengaruh suhu dan waktu ekstraksi terhadap kandungan flavonoid dan aktivitas antioksidan daun sirsak (Annona muricata L.) menggunakan ultrasonik. Media Ilm Tekn Pangan. 2017;4(1):35-42.
  35. Nurhayati LS, Yahdiyani N, Hidayatulloh A. Perbandingan pengujian aktivitas antibakteri starter yogurt dengan metode difusi sumuran dan metode difusi cakram. J Tekn Hasil Petern. 2020;1(2):41-46. https://doi.org/10.24198/jthp.v1i2.27537
  36. Rusmiyati I, Husain DR, Alam G. Bioaktivitas ekstrak metanol daun muda sirsak Annona muricata L. sebagai Antibakteri terhadap Staphylococcus aureus dan Propionibacteriumacnes [internet]. Makassar: Hasanuddin University; 2014 [cited 2023 Jul 25]. Available from: https://core.ac.uk/download/pdf/25494099.pdf
  37. Handayani H, Sriherfyna FH, Yunianta. Ekstraksi antioksidan daun sirsak metode ultrasonic bath (kajian rasio bahan: pelarut dan lama ekstraksi). J Pangan Agroind. 2016;4(1):262-72.
  38. Pramadya P, Hendrayana M. Efek ekstrak metanol daun sirsak (Annona muricata) dalam menghambat pertumbuhan bakteri Salmonella typhi secara in vitro. J Med Udayana. 2021;10(6):97-99. https://doi.org/10.24843.MU.2021.V10.i6.P18
  39. Kotera Y, Aledeh M, Barnes K, Rushforth A, Adam H, Riswani R. Academic motivation of Indonesian University students: relationship with self-compassion and resilience. Healthcare. 2022;10(2092):1-12. https://doi.org/10.3390/healthcare10102092
  40. Khan I, AbdElsalam NM, Fouad H, Tariq A, Ullah R, Adnan M. Application of ethnobotanical indices on the use of traditional medicines against common diseases. Evid Compl Altern Med. 2014;2014(635371):1-22. https://doi.org/10.1155/2014/635371
  41. Ewadh MJ, Smaism MF, Jawad AM, Mkhlof S, Aljubouri OM, Ewadh MM. Using soursop extracts for natural gout treatment. Amer J Biosci Bioeng. 2015;3(5):37-39. https://doi.org/10.11648/j.bio.20150305.12
  42. Drishya G, Nambiar J, Shaji SK, Vanuopadath M, Achuthan A, Kumar A, et al. RECK and TIMP-2 mediate inhibition of MMP-2 and MMP-9 by Annona muricata. J Biosci. 2020;45(89):1-11. https://doi.org/10.1007/s12038-020-00056-z
  43. Pieme CA, Kumar SG, Dongmo MS, Moukette BM, Boyoum FF, Ngogang JY, et al. Antiproliferative activity and induction of apoptosis by Annona muricata (Annonaceae) extract on human cancer cells. BMC Compl Altern Med. 2014;14(516):1-10. https://doi.org/10.1186/1472-6882-14-516
  44. Nwokocha CR, Owu DU, Gordon A, Thaxter K, McCalla G, Ozolua RI, et al. Possible mechanisms of action of the hypotensive effect of Annona muricata (soursop) in normotensive Sprague-Dawley rats. Pharm Biol. 2012;50(11):1436-41. https://doi.org/10.3109/13880209.2012.684690
  45. Adefegha SA, Oyeleye SI, Oboh, G. Distribution of phenolic contents, antidiabetic potentials, antihypertensive properties and antioxidative effects of soursop (Annona muricata L.) fruit parts in vitro. Biochem Res Int. 2015;2015(347673):1-8. https://doi.org/10.1155/2015/347673
  46. Agu KC, Eluehike N, Ofeimun RO, Abile D, Ideho G, Ogedengbe MO, et al. Possible anti-diabetic potentials of Annona muricata (soursop): inhibition of ?-amylase and ?-glucosidase activities. Clin Phytosci. 2019;5(21):1-13. https://doi.org/10.1186/s40816-019-0116-0
  47. Welz AN, Emberger-Klein A, Menrad K. Why people use herbal medicine: insights from a focus-group study in Germany. BMC Compl Altern Med. 2018;18(92):1-9. https://doi.org/10.1186/s12906-018-2160-6
  48. Cebrián E, Domenech J. Is google trends a quality data source? App Eco Lett. 2023;30(6):811-15. https://doi.org/10.1080/13504851.2021.2023088
  49. Kharisma B. Surfing alone? The internet and social capital: evidence from Indonesia. J Eco Struct. 2022;11(8):1-17. https://doi.org/10.1186/s40008-022-00267-7
  50. Sudarmanto IG, Jirna IN. Lulur tradisional daun sirsak menghambat pertumbuhan bakteri Staphylococcus aureus. Solok: Penerbit Mitra Cendekia Media; 2023.

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