Natural Phyto-Active Antihyperglycemic Moieties as Preventive Therapeutics for Diabetes Type II
DOI:
https://doi.org/10.14719/pst.2019.6.sp1.671Keywords:
Antihyperglycemic, Naturopathy, Drug Formulation, Protein MoietiesAbstract
Diabetes mellitus type II (DM II) is a state characterized by hyperglycemia as fallout of endocrine dysfunction. This condition comes under the category of lifestyle diseases. The impaired insulin secretion, resistance or a combination of both results in the dysregulation of carbohydrate, protein and lipid metabolism. The extremities of this state are associated with other detrimental complications such as cardiomyopathy, retinopathy, nephropathy, hepatopathy, neuropathy etc. DM II has now become a growing epidemic and a major health concern globally. Naturopathy deals with the development of promising therapeutics using herbal origin to ensure minimal or no other side effects with best efficacy of the drug as a promising candidate against a diseased condition. Therefore the review aims to find out a range of medicinal plants that can be used as a natural remedy for the management of DM II, through isolation of active plant moieties (specifically proteins) with antihyperglycemic properties. The active plant metabolites, with antidiabetic potential based on the available pharmacological reports are used as herbal cure against DM II. These isolated active plant moieties, possessing antihyperglycemic properties, might play a significant role in the development of a formulation of plant protein moieties (as a preventive therapeutic) to reduce the prevalence of DM II and to serve the mankind.
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References
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2. Standards of medical care in diabetes-2016: Summary of revisions. Diabetes Care. 2016;39(Suppl. 1):S4–5. https://doi.org/10.2337/dc16-S003
3. Tabish SA. Is Diabetes Becoming the Biggest Epidemic of the Twenty-first Century? International Journal of Health Sciences. 2007;1(2):5-8.
4. Goyal R, Jialal I. Diabetes Mellitus Type 2. NCBI Bookshelf. 2019.
5. Shaw JE, Sicree RA, Zimmet PZ. Global estimates of the prevalence of diabetes for 2010 and 2030. Diabetes Research and Clinical Practice. 2010;87(1):4–14. https://doi.org/10.1016/j.diabres.2009.10.007
6. Peiris H, Park S, Louis S, Gu X, Lam JY, Asplund O, et al. Discovering human diabetes-risk gene function with genetics and physiological assays. Nature Communications. 2018;9:3855. https://doi.org/10.1038/s41467-018-06249-3
7. Zheng Y, Ley SH, Hu FB. Diabetes mellitus and its complications. Nature Reviews Endocrinology. 2018;14:88-98. https://doi.org/10.1038/nrendo.2017.151
8. American Diabetes Association. Diagnosis and classification of Diabetes Mellitus. Diabetes Care. 2008;31(1). https://doi.org/10.2337/dc10-S062
9. Choudhury H, Pandey M, Hua CK, Mun CS, Jing JK, Kong L, et al. An update on natural compounds in the remedy of diabetes mellitus: A systematic review. Journal of Traditional and Complementary Medicine. 2018;8(3):361–76. https://doi.org/10.1016/j.jtcme.2017.08.012
10. Wadood A, Wadood N, Shah SA. Effects of Acacia arabica and Caralluma edulis on blood glucose levels on normal and alloxan diabetic rabbits. Journal of Pakistan Medical Association. 1989;39:208–12.
11. Karunanayake EH, Welihinda J, Sirimanne SR, Sinnadorai G. Oral hypoglycemic activity of some medicinal plants of Sri Lanka. Journal of Ethnopharmacology. 1984;11:223–31. https://doi.org/10.1016/0378-8741(84)90040-0
12. Roman-Ramos R, Flores-Saenz JL, Alaricon-Aguilar FJ. Antihyperglycemic effect of some edible plants. Journal of Ethnopharmacology. 1995;48:25–32.
13. Kumari K, Mathew BC, Augusti KT. Antidiabetic and hypolipidaemic effects of S-methyl cysteine sulfoxide, isolated from Allium cepa Linn. Indian Journal of Biochemistry and Biophysics. 1995;32:49–54.
14. Sheela CG, Augusti KT. Antidiabetic effects of S-allylcysteine sulphoxide isolated from garlic Allium sativum Linn. Indian Journal of Experimental Biology. 1992;30:523–26.
15. Al-Awadi FM, Gumaa KA. Studies on the activity of individual plants of an antidiabetic plant mixture. Acta Diabetologica. 1987;24:37–41. https://doi.org/10.1007/bf02732051
16. Ajabnoor MA. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. Journal of Ethnopharmacology. 1990;28:215–20. https://doi.org/10.1016/0378-8741(90)90031-n
17. Davis RH and Maro NP. Aloe vera and gibberellins: Anti-inflammatory activity in diabetes. Journal of American Podiatric Medical Association. 1989;79:24–26. https://doi.org/10.7547/87507315-79-1-24
18. Chattopadhyay RR, Chattopadhyay RN, Nandy AK, Poddar G, Maitra SK. The effect of fresh leaves of Azadiracta indica on glucose uptake and glycogen content in the isolated rat hemidiaphragm. Bulletin of Calcutta School of Tropical Medicine. 1987;35:8–12.
19. Biswas K, Chattopadhyay I, Banerjee RK, Bandyopadhyay U. Biological activities and medicinal properties of neem (Azadiracta indica). Current Science. 2002;82:1336–45.
20. Khosla P, Bhanwra S, Singh J, Seth S, Srivastava R. A study of hypoglycaemic effects of Azadirachta indica (Neem) in normal and alloxan diabetic rabbits. Indian Journal of Physiology and Pharmacology 2000;44(1):69-74.
21. Kumar A, Gnananath K, Gande S, Goud E, Rajesh P, Nagarjuna S. Anti-diabetic Activity of Ethanolic Extract of Achyranthes aspera Leaves in Streptozotocin induced diabetic rats. Journal of Pharmacy Research. 2011;4:3124-25.
22. Andrade-Cetto A, Wiedenfeld H. Hypoglycemic effect of Acosmium panamense bark on streptozotoc in diabetic rats. Journal of Ethnopharmacology. 2004;90(2):217-20. https://doi.org/10.1016/j.jep.2003.09.049
23. Zhang XF, Tan B. Anti-diabetic property of ethanolic extract of Andrographis paniculata in streptozotocin-diabetic rats. Acta Pharmaceutica Sinica. 2000;21(12):1157-64.
24. Kaleem M, Asif M, Ahmed Q, Bano B. Antidiabetic and antioxidant activity of Annona squamosa extract in streptozotocin-induced diabetic rats. Singapore Medical Journal. 2006;47(8):670-75.
25. Kumar S, Alagawadi K. Hypoglycemic effect of Argyreia nervosa root extract in normal and streptozotocin-diabetic rats. Der Pharmacia Lettre. 2010;2(2):333-37.
26. Shamaony L, Khazraji SM, Twaij H A. Hypoglycaemic effect of Artemisia herba alba II. Effect of a valuable extract on some blood parameters in diabetic animals. Journal of Ethnopharmacology. 1994;43(3):167-71. https://doi.org/10.1016/0378-8741(94)90038-8
27. Pushparaj P, Tan C, Tan B. Effects of Averrhoa bilimbi leaf extract on blood glucose and lipids in streptozotocin-diabetic rats. Journal of Ethnopharmacology- 2000;72(1):69-76. https://doi.org/10.1016/s0378-8741(00)00200-2
28. Geetha M, Wahi A. Antidiabetic activity of Barleria prionitis Linn. Journal of Natural Remedies. 2001;1(1):64-66. https://doi.org/10.18311/jnr/2001/65
29. Puri D. The in sulinotropic activity of a Nepalese medicinal plant Biophytum sensitivum: preliminary experimental study. Journal of ethnopharmacology. 2001;78(1):89-93. https://doi.org/10.1016/s0378-8741(01)00306-3
30. Anand P, Murali K, Tandon V, Chandra R, Murthy P. Preliminary studies on antihyperglycemic effect of aqueous extract of Brassica nigra (L.) Koch in streptozotocin induced diabetic rats. Indian Journal of Experimental Biology. 2007;45(8):696-701.
31. Singh R, Rajasree P, Sankar C. Screening for anti-diabetic activity of the ethanolic extract of Bryonia Alba roots. International Journal of Pharma and Biosciences. 2012;2(3):210-15.
32. Sharma S, Dwivedi S, Swarup D. Hypoglycaemic, antihyperglycaemic and hypolipidemic activities of Caesalpinia bonducella seeds in rats. Journal of Ethnopharmacology. 1997;58(1):39-44. https://doi.org/10.1016/s0378-8741(97)00079-2
33. Yadav P, Sarkar S, Bhatnagar D. Lipid peroxidation and antioxidant enzymes in erythrocytes and tissues in aged diabetic rats. Indian Journal of Experimental Biology. 1997;35:389–92.
34. Agarwal V, Chauhan BM. A study on composition and hypolipidemic effect of dietary fiber from some plant foods. Plant Foods for Human Nutrition. 1988;38:189–97. https://doi.org/10.1007/bf01091723
35. Kamble SM, Kamlakar PL, Vaidya S, Bambole VD. Influence of Coccinia indica on certain enzymes in glycolytic and lipolytic pathway in human diabetes. Indian Journal of Medical Sciences. 1998;52:143–46.
36. Dolui A, Segupta R. Antihyperglycemic effect of different solvent extracts of leaves of Cajanus cajan HPLC profile of the active extracts. Asian Journal of Pharmceutical and Clinical Research. 2012;5:116-19.
37. Espósito AM, Diaz A, De Gracia I, De Tello R, Gupta M. Evaluation of traditional medicine: effects of Cajanus cajan L. and of Cassia fistula L. on carbohydrate metabolism in mice. Revistamedica de Panama. 1991;16(1):39-45.
38. Eddouks M, Lemhadri A, Michel JB. Caraway and caper: potential anti-hyperglycaemic plants in diabeticrats. Journal of Ethnopharmacology. 2004;94(1):143-48.
39. Prakasam A, Sethupathy S, Pugalendi KV. Antihyperglycaemic effect of Casearia esculenta root extracts in streptozotocin-induced diabetic rats. Pharmazie. 2002;57(11):758-60.
40. Eddouks M, Lemhadri A, Zeggwagh N, Michel J. Potent hypoglycaemic activity of the aqueous extract of Chamaemelum nobile in normal and streptozotocin-induced diabetic rats. Diabetes Research and Clinical Practice. 2005;67(3):189-95. https://doi.org/10.1016/j.diabres.2004.07.015
41. Pushparaj P, Low H, Manikandan J, Tan B, Tan C. Anti-diabetic effects of Cichorium intybus in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology. 2007; 111(2):430-34. https://doi.org/10.1016/j.jep.2006.11.028
42. Ahangarpour A, Oroojan A. Effect of crust and seed hydro-alcoholic and aqueous extracts and pulp hydroalcoholic extract of Citrullus colocynthis on glucose, insulin and FIRI level in insulin resistant male rat’s. Horizon of Medical Sciences. 2013;19(3):149-54.
43. Naquvi KJ, Ali M, Ahmad J. Antidiabetic activity of aqueous extract of Coriandrum sativum L. fruits in streptozotocin induced rats. Indian Journal of Experimental Biology. 2004;42(9):909-12.
44. Ahangarpour A, Zamaneh TH, Jabari A, Malekshahi Nia H, Heidari H. Antidiabetic and hypolipidemic effects of Dorema aucheri hydroalcoholic leave extract in streptozotocin-nicotinamide induced type 2 diabetes in male rats. Iranian Journal of Basic Medical Sciences. 2014;17(10):808-14.
45. Acherekar S, Kaklij GS, Pote MS, Kelkar SM. Hypoglycemic activity of Eugenia jambolana and Ficus bengalensis: mechanism of action. In vivo. 1991;5:143–47.
46. Ananthi J, Prakasam A, Pugalendi K. Antihyperglycemic activity of Eclipta alba leaf on alloxan-induced diabetic rats. Yale J Biol Med. 2003;76(3):97-102.
47. Eddouks M, Maghrani M. Phlorizin-like effect of Fraxinus excelsior in normal and diabetic rats. Journal of Ethnopharmacology. 2004;94(1):149-54. https://doi.org/10.1016/j.jep.2004.05.005
48. Chakrabarti R, Vikramadithyan RK, Mullangi R, Sharma V, Jagadheshan H, Rao Y. Antidiabetic and hypolipidemic activity of Helicteres isora in animal models. Journal of Ethnopharmacology. 2002;81(3):343-49. https://doi.org/10.1016/s0378-8741(02)00120-4
49. Mahomed IM, Ojewole JA. Hypoglycemic effect of Hypoxis hemerocallidea corm (African potato) aqueous extract in rats. Methods and Findings in Experimental and Clinical Pharmacology. 2003;25(8):617-24. https://doi.org/10.1358/mf.2003.25.8.778082
50. Eddouks M, Maghrani M, Zeggwagh NA, Michel J. Study of the hypoglycaemic activity of Lepidium sativum L. aqueous extract in normal and diabetic rats. Journal of Ethnopharmacology. 2005;97(2):391-95. https://doi.org/10.1016/j.jep.2004.11.030
51. Aderibigbe A, Emudianughe T, Lawal B. Antihyperglycaemic effect of Mangifera indica in rat. Phytotherapy Research. 1999;13(6):504-47. https://doi.org/10.1002/(sici)1099-1573(199909)13:6<504::aid-ptr533>3.0.co;2-9
52. Shibib B A, Khan L A, Rahman R. Hypoglycemic activity of Coccinia indica and Momordica charantia in diabetic rats: depression of the hepatic gluconeogenic enzymes glucose-6-phosphatase and fructose-1, 6-biphosphatase and elevation of liver and red-cell shunt enzyme glucose-6-phosphate dehydrogenase. Biochemical Journal. 1993;292:267–70. https://doi.org/10.1042/bj2920267
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31-12-2019
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Agnihotri P, Kashyap H, Gupta S. Natural Phyto-Active Antihyperglycemic Moieties as Preventive Therapeutics for Diabetes Type II. Plant Sci. Today [Internet]. 2019 Dec. 31 [cited 2024 Dec. 22];6(sp1):551-5. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/671
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