Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy
DOI:
https://doi.org/10.14719/pst.2019.6.2.514Keywords:
Hepatotoxicity, Hepatoprotective, Medicinal herbs, Cancer drugs, ChemotherapyAbstract
Chemotherapy induced-hepatotoxicity is one of the prevalent problems among cancer patients, with a wide spectrum of complications from liver dysfunction to liver necrosis. Therefore, in this study, we review the research findings on the effects of medicinal herbs and herbal compounds on the hepatotoxicity induced by anticancer drugs. The words hepatotoxicity and hepatoprotective along with the words cancer drug or chemotherapy in combination with some herbal terms such as medicinal plant, phyto* and herb* were used to search for relevant publications indexed in the Institute for Scientific Information (ISI) and PubMed. Available evidence shows that certain medicinal plants and herbal derivatives can reduce cancer drug-induced hepatotoxicity and protect liver cells against complications by regulating hepatic enzymes and increasing antioxidant enzyme activities. Some herbal formulations, including traditional Chinese medicine, have also been reported to exhibit such effects. Medicinal plants can exert anti-hepatotoxicity effects mainly by increasing antioxidant activity, inhibiting inflammatory processes, and reducing cell necrosis induced by anti-cancer drugs. Phytotherapy can be used as an effective complementary treatment for anticancer drug-induced hepatotoxicity and prevent various complications in the liver.
Downloads
Download data is not yet available.
References
1. World Health Organization. Cancer: Fact sheet N°297 Genowa: WHO; 2016 [updated February 2015; cited 2016 7/3/2016]. Available from: http://www.who.int/mediacentre/factsheets/fs297/en
2. Kufe DW, Hait W, Holland JF, Frei E, Pollock RE. Holland Frei cancer medicine 8: PMPH-USA; 2010.
3. Edwards BJ, Raisch DW, Saraykar SS, Sun M, Hammel JA, Tran HT, et al. Hepatotoxicity with Vismodegib: An MD Anderson Cancer Center and research on adverse drug events and reports project. Drugs in R&D. 2017;17(1):211-8. https://doi.org/10.1007/s40268-016-0168-2
4. Sharma A, Houshyar R, Bhosale P, Choi J-I, Gulati R, Lall C. Chemotherapy induced liver abnormalities: an imaging perspective. Clinical and Molecular Hepatology. 2014;20(3):317-26. https://doi.org/10.3350/cmh.2014.20.3.317
5. Grigorian A, O'Brien CB. Hepatotoxicity Secondary to Chemotherapy. Journal of Clinical and Translational Hepatology. 2014;2(2):95-102.
6. Vincenzi B, Armento G, Spalato Ceruso M, Catania G, Leakos M, Santini D, et al. Drug-induced hepatotoxicity in cancer patients - implication for treatment. Expert Opinion on Drug Safety. 2016;15(9):1219-38. https://doi.org/10.1080/14740338.2016.1194824
7. Nikfarjam M, Dehkordi KS, Aghaei A, Rahimian G. Efficacy of hypnotherapy in conjunction with pharmacotherapy and pharmacotherapy alone on the quality of life in patients with irritable bowel syndrome. Govaresh. 2013;18(3):149-56.
8. Dehkordi KS, Nikfarjam M, Sanaei S. Effectiveness of mindfulness-based stress reduction training and drug therapy on quality of life in patients with irritable bowel syndrome in Shahrekord. Life Science Journal. 2014;11(9):445-9.
9. Hasanpour-Dehkordi A, Jivad N, Solati K. Effects of yoga on physiological indices, anxiety and social functioning in multiple sclerosis patients: A randomized trial. Journal of Clinical and Diagnostic Research. 2016;10(6):VC01-VC5.
10. Shahbazi K, Solati-Dehkordi K, Dehkordi AH. Comparison of hypnotherapy and standard medical treatment alone on quality of life in patients with irritable bowel syndrome: A randomized control trial. Journal of Clinical and Diagnostic Research. 2016;10(5):OC01-OC4. https://doi.org/10.7860/JCDR/2016/17631.7713
11. Solati K. Effectiveness of cognitive-behavior group therapy, psycho-education family, and drug therapy in reducing and preventing recurrence of symptoms in patients with major depressive disorder. Journal of Chemical and Pharmaceutical Sciences. 2016;9(4):3414-8.
12. Noghabi AAA, Zandi M, Mehran A, Alavian SM, Dehkordi AH. The effect of education on quality of life in patients under interferon therapy. Hepatitis Monthly. 2010;10(3):218-22.
13. Solati K, Mousavi M, Kheiri S, Hasanpour-Dehkordi A. The effectiveness of mindfulness-based cognitive therapy on psychological symptoms and quality of life in systemic lupus erythematosus patients: A randomized controlled trial. Oman Medical Journal. 2017;32(5):378-85. https://doi.org/10.5001/omj.2017.73
14. Rouhi-Boroujeni H, Asadi-Samani M, Moradi MT. A review of the medicinal plants effective on headache based on the ethnobotanical documents of Iran. Der Pharmacia Lettre. 2016;8(3):37-42.
15. Kooti W, Moradi M, Ali-Akbari S, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. Journal of Herbmed Pharmacology. 2015;4(1):1-9.
16. Mohsenzadeh A, Ahmadipour S, Ahmadipour S, Asadi-Samani M. Iran's medicinal plants effective on fever in children: A review. Der Pharmacia Lettre. 2016;8(1):129-34.
17. Parsaei P, Bahmani M, Naghdi N, Asadi-Samani M, Rafieian-Kopaei MM, Boroujeni S. Shigellosis phytotherapy: A review of the most important native medicinal plants in Iran effective on Shigella. Der Pharmacia Lettre. 2016;8(2):249-55.
18. Kooti W, Ghasemiboroon M, Asadi-Samani M, Ahangarpoor A, Zamani M, Amirzargar A, et al. The effect of Halcoholic extract of celery leaves on the delivery rate (fertilization and stillbirths), the number, weight and sex ratio of rat off spring. Advances in Environmental Biology. 2014;8(10):824-30.
19. Hosseini Z, Lorigooini Z, Rafieian-Kopaei M, Shirmardi H, Solati K. A review of botany and pharmacological effect and chemical composition of Echinophora species growing in Iran. Pharmacognosy Research. 2017;9(4):305-12. https://doi.org/10.4103/pr.pr_22_17
20. Heidarian E, Movahed-Mohammadi G, Saffari J, Ghatreh-Samani K. Protective effect of hydroethanolic extract of cress against hepatotoxicity due to acetaminophen in rats. Journal of Mazandaran University of Medical Sciences. 2013;23(102):78-90.
21. Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi-Boroujeni A. Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review. Journal of Nephropathology. 2017;6(3):254-63. https://doi.org/10.15171/jnp.2017.41
22. Memarzadeh E, Luther T, Heidari-Soureshjani S. Effect and Mechanisms of Medicinal Plants on Dry Eye Disease: A Systematic Review. Journal of Clinical and Diagnostic Research. 2018;12(9):NE1-NE4. https://doi.org/10.7860/JCDR/2018/36409.12042
23. Shabanian G, Heidari-Soureshjani S, Rafieian-Kopaei M, Saadat M, Shabanian M. Therapeutic effects of Quercus persica l fruit skin on healing of second-degree burn wounds in animal model. Journal of Zanjan University of Medical Sciences and Health Services. 2017;25(113):81-92.
24. Shabanian S, Khalili S, Lorigooini Z, Malekpour A, Heidari-Soureshjani S. The effect of vaginal cream containing ginger in users of clotrimazole vaginal cream on vaginal candidiasis. Journal of Advanced Pharmaceutical Technology & Research. 2017;8(2):80-4.
25. Shirani M, Raeisi R, Heidari-Soureshjani S, Asadi-Samani M, Luther T. A review for discovering hepatoprotective herbal drugs with least side effects on kidney. Journal of Nephropharmacology. 2017;6(2).
26. Yavangi M, Rabiee S, Nazari S, Farimani-Sanoee M, Amiri I, Bahmanzadeh M, et al. Comparison of the effect of oestrogen plus Foeniculum vulgare seed and oestrogen alone on increase in endometrial thickness in infertile women. Journal of Clinical and Diagnostic Research. 2018;12(1):QC01 – QC4. https://doi.org/10.7860/JCDR/2018/30164.11020
27. Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi-Boroujeni A. Phytotherapy of nephrotoxicity-induced by cancer drugs: An updated review. Journal of Nephropathology. 2017;6(3):254-63. https://doi.org/10.15171/jnp.2017.41
28. Shirani-Boroujeni M, Heidari-Soureshjani S, Keivani Hafshejani Z. Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial. Journal of Renal Injury Prevention. 2017;6(2):127-31. https://doi.org/10.15171/jrip.2017.25
29. Nikfarjam M, Rakhshan R, Ghaderi H. Comparison of effect of Lavandula officinalis and venlafaxine in treating depression: A double blind clinical trial. Journal of Clinical and Diagnostic Research : JCDR. 2017;11(7):KC01-KC4. https://doi.org/10.7860/JCDR/2017/20657.10233
30. Solati K, Heidari-Soureshjani S, Luther T, Asadi-Samani M. Iranian medicinal plants effective on sexual disorders: A systematic review. International Journal of Pharmaceutical Sciences and Research. 2017;8(6):2415-20.
31. Kumari KK, Setty OH. Protective effect of Phyllanthus fraternus against mitochondrial dysfunction induced by co-administration of cisplatin and cyclophosphamide. Journal of Bioenergetics and Biomembranes. 2012;44(1):179-88. https://doi.org/10.1007/s10863-012-9423-6
32. Dkhil MA, Al-Quraishy S, Aref AM, Othman MS, El-Deib KM, Moneim AEA. The potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female rats. Oxidative Medicine and Cellular Longevity. 2013; 741817.
33. Zarei M, Shivanandappa T. Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice. Food and Chemical Toxicology. 2013;57:179-84. https://doi.org/10.1016/j.fct.2013.03.028
34. Zheng XN, Wang XW, Li LY, Xu ZW, Huang HY, Zhao JS, et al. Pu-erh tea powder preventive effects on cisplatin-induced liver oxidative damage in Wistar rats. Asian Pacific Journal of Cancer Prevention. 2014;15(17):7389-94. https://doi.org/10.7314/APJCP.2014.15.17.7389
35. Huang TH, Chiu YH, Chan YL, Wang H, Li TL, Liu CY, et al. Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice. Oncotarget. 2015;6(28):25741-54. https://doi.org/10.18632/oncotarget.4348
36. Devi HP, Mazumder PB. Methanolic extract of Curcuma caesia Roxb. Prevents the toxicity caused by cyclophosphamide to bone marrow cells, liver and kidney of mice. Pharmacognosy Research. 2016;8(1):43-9. https://doi.org/10.4103/0974-8490.171106
37. El-Naggar SA, Abdel-Farid IB, Germoush MO, Elgebaly HA, Alm-Eldeen AA. Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity. Pharmaceutical Biology. 2016;54(10):2007-16. https://doi.org/10.3109/13880209.2015.1137954
38. Tuorkey MJ. Therapeutic potential of Nigella sativa oil against cyclophosphamide-induced DNA damage and hepatotoxicity. Nutrition and Cancer. 2017;69(3):498-504. https://doi.org/10.1080/01635581.2017.1285408
39. Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, et al. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 2010;116(2):506-13. https://doi.org/10.1002/cncr.24723
40. McBride A, Augustin KM, Nobbe J, Westervelt P. Silybum marianum (milk thistle) in the management and prevention of hepatotoxicity in a patient undergoing reinduction therapy for acute myelogenous leukemia. Journal of Oncology Pharmacy Practice. 2012;18(3):360-5. https://doi.org/10.1177/1078155212438252
41. Lata S, Singh S, NathTiwari K, Upadhyay R. Evaluation of the antioxidant and hepatoprotective effect of Phyllanthus fraternus against a chemotherapeutic drug cyclophosphamide. Applied Biochemistry and Biotechnology. 2014;173(8):2163-73. https://doi.org/10.1007/s12010-014-1018-8
42. Ahmadipour A, Sharififar F, Nakhaipour F, Samanian M, Karami-Mohajeri S. Hepatoprotective effect of Zataria Multiflora Boiss on cisplatin-induced oxidative stress in male rat. Journal of Medicine and Life. 2015;8(Spec Iss 4):275-81.
43. Tag HM. Hepatoprotective effect of mulberry (Morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat. BMC Complementary and Alternative Medicine. 2015;15:252. https://doi.org/10.1186/s12906-015-0744-y
44. Zhu H, Long MH, Wu J, Wang MM, Li XY, Shen H, et al. Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid. Scientific Reports. 2015;5:17536. https://doi.org/10.1038/srep17536
45. Ettaya A, Dhibi S, Samout N, Elfeki A, Hfaiedh N. Hepatoprotective activity of white horehound (Marrubium vulgare) extract against cyclophosphamide toxicity in male rats. Canadian Journal of Physiology and Pharmacology. 2016;94(4):441-7. https://doi.org/10.1139/cjpp-2015-0405
46. Sheweita SA, El-Hosseiny LS, Nashashibi MA. Protective effects of essential oils as natural antioxidants against hepatotoxicity induced by cyclophosphamide in mice. PLoS One. 2016;11(11):e0165667. https://doi.org/10.1371/journal.pone.0165667
47. Famurewa AC, Folawiyo AM, Enohnyaket EB, Azubuike-Osu SO, Abi I, Obaje SG, et al. Beneficial role of virgin coconut oil supplementation against acute methotrexate chemotherapy-induced oxidative toxicity and inflammation in rats. Integrative Medicine Research. 2018;7(3):257-63. https://doi.org/10.1016/j.imr.2018.05.001
48. Liu M-L, Chien L-Y, Tai C-J, Lin K-C, Tai C-J. Effectiveness of traditional chinese medicine for liver protection and chemotherapy completion among cancer patients. Evidence-Based Complementary and Alternative Medicine. 2011; 291843. https://doi.org/10.1093/ecam/nep185
49. Gnanasekaran S, Sakthivel KM, Chandrasekaran G. Immunostimulant and chemoprotective effect of vivartana, a polyherbal formulation against cyclophosphamide induced toxicity in Swiss albino mice. Journal of Experimental Therapeutics and Oncology. 2015;11(1):51-61.
50. Gong C, Qian L, Yang H, Ji LL, Wei H, Zhou WB, et al. Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice. BMC Complementary and Alternative Medicine. 2015;15:283. https://doi.org/10.1186/s12906-015-0799-9
51. Li X, Li B, Jia Y. The Hepatoprotective effect of Haoqin Qingdan decoction against liver injury induced by a chemotherapeutic drug cyclophosphamide. Evidence-Based Complementary and Alternative Medicine. 2015;2015:978219-. https://doi.org/10.1155/2015/978219
52. Oyagbemi AA, Omobowale OT, Asenuga ER, Akinleye AS, Ogunsanwo RO, Saba AB. Cyclophosphamide-induced hepatotoxicity in Wistar Rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical. International Journal of Preventive Medicine. 2016;7:51. https://doi.org/10.4103/2008-7802.177898
53. Olayinka ET, Ore A, Ola OS, Adeyemo OA. Ameliorative effect of gallic acid on cyclophosphamide-induced oxidative injury and hepatic dysfunction in rats. Medical Sciences (Basel, Switzerland). 2015;3(3):78-92. https://doi.org/10.3390/medsci3030078
54. Wu J, Xue X, Zhang B, Jiang W, Cao H, Wang R, et al. The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway. Chemico-Biological Interactions. 2016;244:1-8. https://doi.org/10.1016/j.cbi.2015.11.025
55. Gao Y, Chu S, Shao Q, Zhang M, Xia C, Wang Y, et al. Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice. Free Radical Research. 2017;51(1):1-13. https://doi.org/10.1080/10715762.2016.1234710
56. Abdelmeguid NE, Chmaisse HN, Abou Zeinab NS. Silymarin ameliorates cisplatin-induced hepatotoxicity in rats: histopathological and ultrastructural studies. Pakistan Journal of Biological Sciences. 2010;13(10):463-79. https://doi.org/10.3923/pjbs.2010.463.479
57. Hagag AA, Elgamsy MA, El-Asy HM, Mabrouk MM. Protective Role of silymarin on hepatic and renal toxicity induced by MTX based chemotherapy in children with acute lymphoblastic leukemia. Mediterranean Journal of Hematology and Infectious Diseases. 2016;8(1):e2016043. https://doi.org/10.4084/mjhid.2016.043
58. Olayinka ET, Ore A, Ola OS, Adeyemo OA. Protective effect of quercetin on melphalan-induced oxidative stress and impaired renal and hepatic functions in rat. Chemotherapy Research and Practice. 2014; 936526. https://doi.org/10.1155/2014/936526
59. Schwingel TE, Klein CP, Nicoletti NF, Dora CL, Hadrich G, Bica CG, et al. Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2014;387(9):837-48. https://doi.org/10.1007/s00210-014-0994-0
60. Lin Y, Li Y, Hu X, Liu Z, Chen J, Lu Y, et al. The hepatoprotective role of reduced glutathione and its underlying mechanism in oxaliplatin-induced acute liver injury. Oncology Letters. 2018;15(2):2266-72.
61. Mehrzadi S, Fatemi I, Esmaeilizadeh M, Ghaznavi H, Kalantar H, Goudarzi M. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomedicine & Pharmacotherapy. 2018;97:233-9. https://doi.org/10.1016/j.biopha.2017.10.113
62. Mir BA, Amin I, Rehman MU, Razak R, Ali A, Baba OK, et al. Chemoprotective potentialo Zingerone (Vanillyl Acetone) in cyclophosphamide-induced hepatic toxicity. Pharmacognosy Magazine. 2018;14(57):S434-S9. https://doi.org/10.4103/pm.pm_170_16
63. Farghali H, Canova NK, Zakhari S. Hepatoprotective properties of extensively studied medicinal plant active constituents: possible common mechanisms. Pharmaceutical Biology. 2015;53(6):781-91. https://doi.org/10.3109/13880209.2014.950387
64. Karami M, Salehi H, Naghshvar F. Study of histopathology and antioxidant activity of methanolic extract of Feijoa sellowiana against dosage induced by MDMA in mouse liver. Pharmacologyonline. 2008;3:315-21.
65. Lina SMM, Ashab I, Ishtiaq Ahmed M, Shahriar M. Hepatoprotective activity of Asteracantha longifolia (Nees.) extract against anti-tuberculosis drugs induced hepatic damage in Sprague-Dawley rats. Pharmacologyonline. 2012;3:13-9.
66. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP. Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-iduced oxidative damage in rats. Chemico-Biological Interactions. 2008;171(3):283-93. https://doi.org/10.1016/j.cbi.2007.08.008
67. Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats. Biological Research. 2010;43(1):113-25. https://doi.org/10.4067/S0716-97602010000100013
68. Jiang Y, Wang C, Li YY, Wang XC, An JD, Wang YJ, et al. Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-beta/Smad interference. Journal of Ethnopharmacology. 2014;158 Pt A:230-8.
69. Zhang W, Zhang X, Zou K, Xie J, Zhao S, Liu J, et al. Seabuckthorn berry polysaccharide protects against carbon tetrachloride-induced hepatotoxicity in mice: Via anti-oxidative and anti-inflammatory activities. Food and Function. 2017;8(9):3130-8. https://doi.org/10.1039/C7FO00399D
70. Choedon T, Shukla SK, Kumar V. Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. Journal of Ethnopharmacology. 2010;129(2):208-13. https://doi.org/10.1016/j.jep.2010.03.011
71. Freise C, Ruehl M, Erben U, Neumann U, Seehofer D, Kim KY, et al. A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines. BMC Complementary and Alternative Medicine. 2011;11:39. https://doi.org/10.1186/1472-6882-11-39
72. Yam MF, Ang LF, Lim CP, Ameer OZ, Salman IM, Ahmad M, et al. Antioxidant and hepatoprotective effects of Murdannia bracteata methanol extract. Journal of Acupuncture and Meridian Studies. 2010;3(3):197-202. https://doi.org/10.1016/S2005-2901(10)60036-2
73. Xu R, Ye H, Sun Y, Tu Y, Zeng X. Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis). Food and Chemical Toxicology. 2012;50(7):2473-80. https://doi.org/10.1016/j.fct.2011.10.047
74. Niu C, Sheng Y, Yang R, Lu B, Bai Q, Ji L, et al. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. Journal of Ethnopharmacology. 2015;164:301-8. https://doi.org/10.1016/j.jep.2015.02.031
75. Lv L, Zheng L, Dong D, Xu L, Yin L, Xu Y, et al. Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. Food and Chemical Toxicology. 2013;59:657-69. https://doi.org/10.1016/j.fct.2013.07.012
76. Zhu J, Viñas R, Smith EE. In vitro evaluation of human liver cancer cells and the potential cytotoxicity of Tecoma stans (Bignoniaceae) and Brickellia cavanillesi (Asteraceae) both single and in combination. Toxicological and Environmental Chemistry. 2008;90(4):801-8. https://doi.org/10.1080/02772240701740387
77. Wang ZY, Kang H, Ji LL, Yang YQ, Liu TY, Cao ZW, et al. Proteomic characterization of the possible molecular targets of pyrrolizidine alkaloid isoline-induced hepatotoxicity. Environmental Toxicology and Pharmacology. 2012;34(2):608-17. https://doi.org/10.1016/j.etap.2012.06.013
78. Niu C, Wang J, Ji L, Wang Z. Protection of Angelica sinensis (Oliv) diels against hepatotoxicity induced by Dioscorea bulbifera L. And its mechanism. BioScience Trends. 2014;8(5):253-9. https://doi.org/10.5582/bst.2014.01076
79. Bishayee A, Darvesh AS, Politis T, McGory R. Resveratrol and liver disease: from bench to bedside and community. Liver International. 2010;30(8):1103-14. https://doi.org/10.1111/j.1478-3231.2010.02295.x
80. Baradaran A, Nasri H, Rafieian-Kopaei M. Comment on: anti-oxidative stress activity of stachys lavandulifolia aqueous extract in humans. Cell Journal. 2013;15(3):272-3.
81. Murakami A. Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents. Archives of Biochemistry and Biophysics. 2014;557:3-10. https://doi.org/10.1016/j.abb.2014.04.018
82. Stiborova M, Hajek M, Frei E, Schmeiser HH. Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH: cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy. General Physiology and Biophysics. 2001; 20(4):375-92.
83. Patel SS, Beer S, Kearney DL, Phillips G, Carter BA. Green tea extract: a potential cause of acute liver failure. World Journal of Gastroenterology. 2013;19(31):5174-7. https://doi.org/10.3748/wjg.v19.i31.5174
84. Wang Y, Deng L, Wang Y, Zhong H, Jiang X, Chen J. Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells. Molecular Medicine Reports. 2011;4(4):713-8.
85. Chang HL, Hsu HK, Su JH, Wang PH, Chung YF, Chia YC, et al. The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model. Gynecologic Oncology. 2006;102(2):309-14. https://doi.org/10.1016/j.ygyno.2005.12.023
86. Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? Journal of the National Cancer Institute. 2008;100(11):773-83. https://doi.org/10.1093/jnci/djn148
87. Mut-Salud N, Álvarez PJ, Garrido JM, Carrasco E, Aránega A, Rodríguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxidative Medicine and Cellular Longevity. 2016; 2016:6719534. https://doi.org/10.1155/2016/6719534
88. Yap KY, See CS, Chan A. Clinically-relevant chemotherapy interactions with complementary and alternative medicines in patients with cancer. Recent Patents on Food, Nutrition & Agriculture. 2010;2(1):12-55. https://doi.org/10.2174/2212798411002010012
89. Efferth T, Schottler U, Krishna S, Schmiedek P, Wenz F, Giordano FA. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature. Archives of Toxicology. 2017;91(4):1833-46. https://doi.org/10.1007/s00204-016-1810-z
2. Kufe DW, Hait W, Holland JF, Frei E, Pollock RE. Holland Frei cancer medicine 8: PMPH-USA; 2010.
3. Edwards BJ, Raisch DW, Saraykar SS, Sun M, Hammel JA, Tran HT, et al. Hepatotoxicity with Vismodegib: An MD Anderson Cancer Center and research on adverse drug events and reports project. Drugs in R&D. 2017;17(1):211-8. https://doi.org/10.1007/s40268-016-0168-2
4. Sharma A, Houshyar R, Bhosale P, Choi J-I, Gulati R, Lall C. Chemotherapy induced liver abnormalities: an imaging perspective. Clinical and Molecular Hepatology. 2014;20(3):317-26. https://doi.org/10.3350/cmh.2014.20.3.317
5. Grigorian A, O'Brien CB. Hepatotoxicity Secondary to Chemotherapy. Journal of Clinical and Translational Hepatology. 2014;2(2):95-102.
6. Vincenzi B, Armento G, Spalato Ceruso M, Catania G, Leakos M, Santini D, et al. Drug-induced hepatotoxicity in cancer patients - implication for treatment. Expert Opinion on Drug Safety. 2016;15(9):1219-38. https://doi.org/10.1080/14740338.2016.1194824
7. Nikfarjam M, Dehkordi KS, Aghaei A, Rahimian G. Efficacy of hypnotherapy in conjunction with pharmacotherapy and pharmacotherapy alone on the quality of life in patients with irritable bowel syndrome. Govaresh. 2013;18(3):149-56.
8. Dehkordi KS, Nikfarjam M, Sanaei S. Effectiveness of mindfulness-based stress reduction training and drug therapy on quality of life in patients with irritable bowel syndrome in Shahrekord. Life Science Journal. 2014;11(9):445-9.
9. Hasanpour-Dehkordi A, Jivad N, Solati K. Effects of yoga on physiological indices, anxiety and social functioning in multiple sclerosis patients: A randomized trial. Journal of Clinical and Diagnostic Research. 2016;10(6):VC01-VC5.
10. Shahbazi K, Solati-Dehkordi K, Dehkordi AH. Comparison of hypnotherapy and standard medical treatment alone on quality of life in patients with irritable bowel syndrome: A randomized control trial. Journal of Clinical and Diagnostic Research. 2016;10(5):OC01-OC4. https://doi.org/10.7860/JCDR/2016/17631.7713
11. Solati K. Effectiveness of cognitive-behavior group therapy, psycho-education family, and drug therapy in reducing and preventing recurrence of symptoms in patients with major depressive disorder. Journal of Chemical and Pharmaceutical Sciences. 2016;9(4):3414-8.
12. Noghabi AAA, Zandi M, Mehran A, Alavian SM, Dehkordi AH. The effect of education on quality of life in patients under interferon therapy. Hepatitis Monthly. 2010;10(3):218-22.
13. Solati K, Mousavi M, Kheiri S, Hasanpour-Dehkordi A. The effectiveness of mindfulness-based cognitive therapy on psychological symptoms and quality of life in systemic lupus erythematosus patients: A randomized controlled trial. Oman Medical Journal. 2017;32(5):378-85. https://doi.org/10.5001/omj.2017.73
14. Rouhi-Boroujeni H, Asadi-Samani M, Moradi MT. A review of the medicinal plants effective on headache based on the ethnobotanical documents of Iran. Der Pharmacia Lettre. 2016;8(3):37-42.
15. Kooti W, Moradi M, Ali-Akbari S, Sharafi-Ahvazi N, Asadi-Samani M, Ashtary-Larky D. Therapeutic and pharmacological potential of Foeniculum vulgare Mill: A review. Journal of Herbmed Pharmacology. 2015;4(1):1-9.
16. Mohsenzadeh A, Ahmadipour S, Ahmadipour S, Asadi-Samani M. Iran's medicinal plants effective on fever in children: A review. Der Pharmacia Lettre. 2016;8(1):129-34.
17. Parsaei P, Bahmani M, Naghdi N, Asadi-Samani M, Rafieian-Kopaei MM, Boroujeni S. Shigellosis phytotherapy: A review of the most important native medicinal plants in Iran effective on Shigella. Der Pharmacia Lettre. 2016;8(2):249-55.
18. Kooti W, Ghasemiboroon M, Asadi-Samani M, Ahangarpoor A, Zamani M, Amirzargar A, et al. The effect of Halcoholic extract of celery leaves on the delivery rate (fertilization and stillbirths), the number, weight and sex ratio of rat off spring. Advances in Environmental Biology. 2014;8(10):824-30.
19. Hosseini Z, Lorigooini Z, Rafieian-Kopaei M, Shirmardi H, Solati K. A review of botany and pharmacological effect and chemical composition of Echinophora species growing in Iran. Pharmacognosy Research. 2017;9(4):305-12. https://doi.org/10.4103/pr.pr_22_17
20. Heidarian E, Movahed-Mohammadi G, Saffari J, Ghatreh-Samani K. Protective effect of hydroethanolic extract of cress against hepatotoxicity due to acetaminophen in rats. Journal of Mazandaran University of Medical Sciences. 2013;23(102):78-90.
21. Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi-Boroujeni A. Phytotherapy of nephrotoxicity-induced by cancer drugs: an updated review. Journal of Nephropathology. 2017;6(3):254-63. https://doi.org/10.15171/jnp.2017.41
22. Memarzadeh E, Luther T, Heidari-Soureshjani S. Effect and Mechanisms of Medicinal Plants on Dry Eye Disease: A Systematic Review. Journal of Clinical and Diagnostic Research. 2018;12(9):NE1-NE4. https://doi.org/10.7860/JCDR/2018/36409.12042
23. Shabanian G, Heidari-Soureshjani S, Rafieian-Kopaei M, Saadat M, Shabanian M. Therapeutic effects of Quercus persica l fruit skin on healing of second-degree burn wounds in animal model. Journal of Zanjan University of Medical Sciences and Health Services. 2017;25(113):81-92.
24. Shabanian S, Khalili S, Lorigooini Z, Malekpour A, Heidari-Soureshjani S. The effect of vaginal cream containing ginger in users of clotrimazole vaginal cream on vaginal candidiasis. Journal of Advanced Pharmaceutical Technology & Research. 2017;8(2):80-4.
25. Shirani M, Raeisi R, Heidari-Soureshjani S, Asadi-Samani M, Luther T. A review for discovering hepatoprotective herbal drugs with least side effects on kidney. Journal of Nephropharmacology. 2017;6(2).
26. Yavangi M, Rabiee S, Nazari S, Farimani-Sanoee M, Amiri I, Bahmanzadeh M, et al. Comparison of the effect of oestrogen plus Foeniculum vulgare seed and oestrogen alone on increase in endometrial thickness in infertile women. Journal of Clinical and Diagnostic Research. 2018;12(1):QC01 – QC4. https://doi.org/10.7860/JCDR/2018/30164.11020
27. Heidari-Soreshjani S, Asadi-Samani M, Yang Q, Saeedi-Boroujeni A. Phytotherapy of nephrotoxicity-induced by cancer drugs: An updated review. Journal of Nephropathology. 2017;6(3):254-63. https://doi.org/10.15171/jnp.2017.41
28. Shirani-Boroujeni M, Heidari-Soureshjani S, Keivani Hafshejani Z. Impact of oral capsule of Peganum harmala on alleviating urinary symptoms in men with benign prostatic hyperplasia; a randomized clinical trial. Journal of Renal Injury Prevention. 2017;6(2):127-31. https://doi.org/10.15171/jrip.2017.25
29. Nikfarjam M, Rakhshan R, Ghaderi H. Comparison of effect of Lavandula officinalis and venlafaxine in treating depression: A double blind clinical trial. Journal of Clinical and Diagnostic Research : JCDR. 2017;11(7):KC01-KC4. https://doi.org/10.7860/JCDR/2017/20657.10233
30. Solati K, Heidari-Soureshjani S, Luther T, Asadi-Samani M. Iranian medicinal plants effective on sexual disorders: A systematic review. International Journal of Pharmaceutical Sciences and Research. 2017;8(6):2415-20.
31. Kumari KK, Setty OH. Protective effect of Phyllanthus fraternus against mitochondrial dysfunction induced by co-administration of cisplatin and cyclophosphamide. Journal of Bioenergetics and Biomembranes. 2012;44(1):179-88. https://doi.org/10.1007/s10863-012-9423-6
32. Dkhil MA, Al-Quraishy S, Aref AM, Othman MS, El-Deib KM, Moneim AEA. The potential role of Azadirachta indica treatment on cisplatin-induced hepatotoxicity and oxidative stress in female rats. Oxidative Medicine and Cellular Longevity. 2013; 741817.
33. Zarei M, Shivanandappa T. Amelioration of cyclophosphamide-induced hepatotoxicity by the root extract of Decalepis hamiltonii in mice. Food and Chemical Toxicology. 2013;57:179-84. https://doi.org/10.1016/j.fct.2013.03.028
34. Zheng XN, Wang XW, Li LY, Xu ZW, Huang HY, Zhao JS, et al. Pu-erh tea powder preventive effects on cisplatin-induced liver oxidative damage in Wistar rats. Asian Pacific Journal of Cancer Prevention. 2014;15(17):7389-94. https://doi.org/10.7314/APJCP.2014.15.17.7389
35. Huang TH, Chiu YH, Chan YL, Wang H, Li TL, Liu CY, et al. Antrodia cinnamomea alleviates cisplatin-induced hepatotoxicity and enhances chemo-sensitivity of line-1 lung carcinoma xenografted in BALB/cByJ mice. Oncotarget. 2015;6(28):25741-54. https://doi.org/10.18632/oncotarget.4348
36. Devi HP, Mazumder PB. Methanolic extract of Curcuma caesia Roxb. Prevents the toxicity caused by cyclophosphamide to bone marrow cells, liver and kidney of mice. Pharmacognosy Research. 2016;8(1):43-9. https://doi.org/10.4103/0974-8490.171106
37. El-Naggar SA, Abdel-Farid IB, Germoush MO, Elgebaly HA, Alm-Eldeen AA. Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity. Pharmaceutical Biology. 2016;54(10):2007-16. https://doi.org/10.3109/13880209.2015.1137954
38. Tuorkey MJ. Therapeutic potential of Nigella sativa oil against cyclophosphamide-induced DNA damage and hepatotoxicity. Nutrition and Cancer. 2017;69(3):498-504. https://doi.org/10.1080/01635581.2017.1285408
39. Ladas EJ, Kroll DJ, Oberlies NH, Cheng B, Ndao DH, Rheingold SR, et al. A randomized, controlled, double-blind, pilot study of milk thistle for the treatment of hepatotoxicity in childhood acute lymphoblastic leukemia (ALL). Cancer. 2010;116(2):506-13. https://doi.org/10.1002/cncr.24723
40. McBride A, Augustin KM, Nobbe J, Westervelt P. Silybum marianum (milk thistle) in the management and prevention of hepatotoxicity in a patient undergoing reinduction therapy for acute myelogenous leukemia. Journal of Oncology Pharmacy Practice. 2012;18(3):360-5. https://doi.org/10.1177/1078155212438252
41. Lata S, Singh S, NathTiwari K, Upadhyay R. Evaluation of the antioxidant and hepatoprotective effect of Phyllanthus fraternus against a chemotherapeutic drug cyclophosphamide. Applied Biochemistry and Biotechnology. 2014;173(8):2163-73. https://doi.org/10.1007/s12010-014-1018-8
42. Ahmadipour A, Sharififar F, Nakhaipour F, Samanian M, Karami-Mohajeri S. Hepatoprotective effect of Zataria Multiflora Boiss on cisplatin-induced oxidative stress in male rat. Journal of Medicine and Life. 2015;8(Spec Iss 4):275-81.
43. Tag HM. Hepatoprotective effect of mulberry (Morus nigra) leaves extract against methotrexate induced hepatotoxicity in male albino rat. BMC Complementary and Alternative Medicine. 2015;15:252. https://doi.org/10.1186/s12906-015-0744-y
44. Zhu H, Long MH, Wu J, Wang MM, Li XY, Shen H, et al. Ginseng alleviates cyclophosphamide-induced hepatotoxicity via reversing disordered homeostasis of glutathione and bile acid. Scientific Reports. 2015;5:17536. https://doi.org/10.1038/srep17536
45. Ettaya A, Dhibi S, Samout N, Elfeki A, Hfaiedh N. Hepatoprotective activity of white horehound (Marrubium vulgare) extract against cyclophosphamide toxicity in male rats. Canadian Journal of Physiology and Pharmacology. 2016;94(4):441-7. https://doi.org/10.1139/cjpp-2015-0405
46. Sheweita SA, El-Hosseiny LS, Nashashibi MA. Protective effects of essential oils as natural antioxidants against hepatotoxicity induced by cyclophosphamide in mice. PLoS One. 2016;11(11):e0165667. https://doi.org/10.1371/journal.pone.0165667
47. Famurewa AC, Folawiyo AM, Enohnyaket EB, Azubuike-Osu SO, Abi I, Obaje SG, et al. Beneficial role of virgin coconut oil supplementation against acute methotrexate chemotherapy-induced oxidative toxicity and inflammation in rats. Integrative Medicine Research. 2018;7(3):257-63. https://doi.org/10.1016/j.imr.2018.05.001
48. Liu M-L, Chien L-Y, Tai C-J, Lin K-C, Tai C-J. Effectiveness of traditional chinese medicine for liver protection and chemotherapy completion among cancer patients. Evidence-Based Complementary and Alternative Medicine. 2011; 291843. https://doi.org/10.1093/ecam/nep185
49. Gnanasekaran S, Sakthivel KM, Chandrasekaran G. Immunostimulant and chemoprotective effect of vivartana, a polyherbal formulation against cyclophosphamide induced toxicity in Swiss albino mice. Journal of Experimental Therapeutics and Oncology. 2015;11(1):51-61.
50. Gong C, Qian L, Yang H, Ji LL, Wei H, Zhou WB, et al. Hepatotoxicity and pharmacokinetics of cisplatin in combination therapy with a traditional Chinese medicine compound of Zengmian Yiliu granules in ICR mice and SKOV-3-bearing nude mice. BMC Complementary and Alternative Medicine. 2015;15:283. https://doi.org/10.1186/s12906-015-0799-9
51. Li X, Li B, Jia Y. The Hepatoprotective effect of Haoqin Qingdan decoction against liver injury induced by a chemotherapeutic drug cyclophosphamide. Evidence-Based Complementary and Alternative Medicine. 2015;2015:978219-. https://doi.org/10.1155/2015/978219
52. Oyagbemi AA, Omobowale OT, Asenuga ER, Akinleye AS, Ogunsanwo RO, Saba AB. Cyclophosphamide-induced hepatotoxicity in Wistar Rats: The modulatory role of gallic acid as a hepatoprotective and chemopreventive phytochemical. International Journal of Preventive Medicine. 2016;7:51. https://doi.org/10.4103/2008-7802.177898
53. Olayinka ET, Ore A, Ola OS, Adeyemo OA. Ameliorative effect of gallic acid on cyclophosphamide-induced oxidative injury and hepatic dysfunction in rats. Medical Sciences (Basel, Switzerland). 2015;3(3):78-92. https://doi.org/10.3390/medsci3030078
54. Wu J, Xue X, Zhang B, Jiang W, Cao H, Wang R, et al. The protective effects of paeonol against epirubicin-induced hepatotoxicity in 4T1-tumor bearing mice via inhibition of the PI3K/Akt/NF-kB pathway. Chemico-Biological Interactions. 2016;244:1-8. https://doi.org/10.1016/j.cbi.2015.11.025
55. Gao Y, Chu S, Shao Q, Zhang M, Xia C, Wang Y, et al. Antioxidant activities of ginsenoside Rg1 against cisplatin-induced hepatic injury through Nrf2 signaling pathway in mice. Free Radical Research. 2017;51(1):1-13. https://doi.org/10.1080/10715762.2016.1234710
56. Abdelmeguid NE, Chmaisse HN, Abou Zeinab NS. Silymarin ameliorates cisplatin-induced hepatotoxicity in rats: histopathological and ultrastructural studies. Pakistan Journal of Biological Sciences. 2010;13(10):463-79. https://doi.org/10.3923/pjbs.2010.463.479
57. Hagag AA, Elgamsy MA, El-Asy HM, Mabrouk MM. Protective Role of silymarin on hepatic and renal toxicity induced by MTX based chemotherapy in children with acute lymphoblastic leukemia. Mediterranean Journal of Hematology and Infectious Diseases. 2016;8(1):e2016043. https://doi.org/10.4084/mjhid.2016.043
58. Olayinka ET, Ore A, Ola OS, Adeyemo OA. Protective effect of quercetin on melphalan-induced oxidative stress and impaired renal and hepatic functions in rat. Chemotherapy Research and Practice. 2014; 936526. https://doi.org/10.1155/2014/936526
59. Schwingel TE, Klein CP, Nicoletti NF, Dora CL, Hadrich G, Bica CG, et al. Effects of the compounds resveratrol, rutin, quercetin, and quercetin nanoemulsion on oxaliplatin-induced hepatotoxicity and neurotoxicity in mice. Naunyn-Schmiedeberg's Archives of Pharmacology. 2014;387(9):837-48. https://doi.org/10.1007/s00210-014-0994-0
60. Lin Y, Li Y, Hu X, Liu Z, Chen J, Lu Y, et al. The hepatoprotective role of reduced glutathione and its underlying mechanism in oxaliplatin-induced acute liver injury. Oncology Letters. 2018;15(2):2266-72.
61. Mehrzadi S, Fatemi I, Esmaeilizadeh M, Ghaznavi H, Kalantar H, Goudarzi M. Hepatoprotective effect of berberine against methotrexate induced liver toxicity in rats. Biomedicine & Pharmacotherapy. 2018;97:233-9. https://doi.org/10.1016/j.biopha.2017.10.113
62. Mir BA, Amin I, Rehman MU, Razak R, Ali A, Baba OK, et al. Chemoprotective potentialo Zingerone (Vanillyl Acetone) in cyclophosphamide-induced hepatic toxicity. Pharmacognosy Magazine. 2018;14(57):S434-S9. https://doi.org/10.4103/pm.pm_170_16
63. Farghali H, Canova NK, Zakhari S. Hepatoprotective properties of extensively studied medicinal plant active constituents: possible common mechanisms. Pharmaceutical Biology. 2015;53(6):781-91. https://doi.org/10.3109/13880209.2014.950387
64. Karami M, Salehi H, Naghshvar F. Study of histopathology and antioxidant activity of methanolic extract of Feijoa sellowiana against dosage induced by MDMA in mouse liver. Pharmacologyonline. 2008;3:315-21.
65. Lina SMM, Ashab I, Ishtiaq Ahmed M, Shahriar M. Hepatoprotective activity of Asteracantha longifolia (Nees.) extract against anti-tuberculosis drugs induced hepatic damage in Sprague-Dawley rats. Pharmacologyonline. 2012;3:13-9.
66. Lin HM, Tseng HC, Wang CJ, Lin JJ, Lo CW, Chou FP. Hepatoprotective effects of Solanum nigrum Linn extract against CCl4-iduced oxidative damage in rats. Chemico-Biological Interactions. 2008;171(3):283-93. https://doi.org/10.1016/j.cbi.2007.08.008
67. Pradeep K, Mohan CVR, Gobianand K, Karthikeyan S. Protective effect of Cassia fistula Linn. on diethylnitrosamine induced hepatocellular damage and oxidative stress in ethanol pretreated rats. Biological Research. 2010;43(1):113-25. https://doi.org/10.4067/S0716-97602010000100013
68. Jiang Y, Wang C, Li YY, Wang XC, An JD, Wang YJ, et al. Mistletoe alkaloid fractions alleviates carbon tetrachloride-induced liver fibrosis through inhibition of hepatic stellate cell activation via TGF-beta/Smad interference. Journal of Ethnopharmacology. 2014;158 Pt A:230-8.
69. Zhang W, Zhang X, Zou K, Xie J, Zhao S, Liu J, et al. Seabuckthorn berry polysaccharide protects against carbon tetrachloride-induced hepatotoxicity in mice: Via anti-oxidative and anti-inflammatory activities. Food and Function. 2017;8(9):3130-8. https://doi.org/10.1039/C7FO00399D
70. Choedon T, Shukla SK, Kumar V. Chemopreventive and anti-cancer properties of the aqueous extract of flowers of Butea monosperma. Journal of Ethnopharmacology. 2010;129(2):208-13. https://doi.org/10.1016/j.jep.2010.03.011
71. Freise C, Ruehl M, Erben U, Neumann U, Seehofer D, Kim KY, et al. A hepatoprotective Lindera obtusiloba extract suppresses growth and attenuates insulin like growth factor-1 receptor signaling and NF-kappaB activity in human liver cancer cell lines. BMC Complementary and Alternative Medicine. 2011;11:39. https://doi.org/10.1186/1472-6882-11-39
72. Yam MF, Ang LF, Lim CP, Ameer OZ, Salman IM, Ahmad M, et al. Antioxidant and hepatoprotective effects of Murdannia bracteata methanol extract. Journal of Acupuncture and Meridian Studies. 2010;3(3):197-202. https://doi.org/10.1016/S2005-2901(10)60036-2
73. Xu R, Ye H, Sun Y, Tu Y, Zeng X. Preparation, preliminary characterization, antioxidant, hepatoprotective and antitumor activities of polysaccharides from the flower of tea plant (Camellia sinensis). Food and Chemical Toxicology. 2012;50(7):2473-80. https://doi.org/10.1016/j.fct.2011.10.047
74. Niu C, Sheng Y, Yang R, Lu B, Bai Q, Ji L, et al. Scutellarin protects against the liver injury induced by diosbulbin B in mice and its mechanism. Journal of Ethnopharmacology. 2015;164:301-8. https://doi.org/10.1016/j.jep.2015.02.031
75. Lv L, Zheng L, Dong D, Xu L, Yin L, Xu Y, et al. Dioscin, a natural steroid saponin, induces apoptosis and DNA damage through reactive oxygen species: a potential new drug for treatment of glioblastoma multiforme. Food and Chemical Toxicology. 2013;59:657-69. https://doi.org/10.1016/j.fct.2013.07.012
76. Zhu J, Viñas R, Smith EE. In vitro evaluation of human liver cancer cells and the potential cytotoxicity of Tecoma stans (Bignoniaceae) and Brickellia cavanillesi (Asteraceae) both single and in combination. Toxicological and Environmental Chemistry. 2008;90(4):801-8. https://doi.org/10.1080/02772240701740387
77. Wang ZY, Kang H, Ji LL, Yang YQ, Liu TY, Cao ZW, et al. Proteomic characterization of the possible molecular targets of pyrrolizidine alkaloid isoline-induced hepatotoxicity. Environmental Toxicology and Pharmacology. 2012;34(2):608-17. https://doi.org/10.1016/j.etap.2012.06.013
78. Niu C, Wang J, Ji L, Wang Z. Protection of Angelica sinensis (Oliv) diels against hepatotoxicity induced by Dioscorea bulbifera L. And its mechanism. BioScience Trends. 2014;8(5):253-9. https://doi.org/10.5582/bst.2014.01076
79. Bishayee A, Darvesh AS, Politis T, McGory R. Resveratrol and liver disease: from bench to bedside and community. Liver International. 2010;30(8):1103-14. https://doi.org/10.1111/j.1478-3231.2010.02295.x
80. Baradaran A, Nasri H, Rafieian-Kopaei M. Comment on: anti-oxidative stress activity of stachys lavandulifolia aqueous extract in humans. Cell Journal. 2013;15(3):272-3.
81. Murakami A. Dose-dependent functionality and toxicity of green tea polyphenols in experimental rodents. Archives of Biochemistry and Biophysics. 2014;557:3-10. https://doi.org/10.1016/j.abb.2014.04.018
82. Stiborova M, Hajek M, Frei E, Schmeiser HH. Carcinogenic and nephrotoxic alkaloids aristolochic acids upon activation by NADPH: cytochrome P450 reductase form adducts found in DNA of patients with Chinese herbs nephropathy. General Physiology and Biophysics. 2001; 20(4):375-92.
83. Patel SS, Beer S, Kearney DL, Phillips G, Carter BA. Green tea extract: a potential cause of acute liver failure. World Journal of Gastroenterology. 2013;19(31):5174-7. https://doi.org/10.3748/wjg.v19.i31.5174
84. Wang Y, Deng L, Wang Y, Zhong H, Jiang X, Chen J. Natural plant extract tubeimoside I induces cytotoxicity via the mitochondrial pathway in human normal liver cells. Molecular Medicine Reports. 2011;4(4):713-8.
85. Chang HL, Hsu HK, Su JH, Wang PH, Chung YF, Chia YC, et al. The fractionated Toona sinensis leaf extract induces apoptosis of human ovarian cancer cells and inhibits tumor growth in a murine xenograft model. Gynecologic Oncology. 2006;102(2):309-14. https://doi.org/10.1016/j.ygyno.2005.12.023
86. Lawenda BD, Kelly KM, Ladas EJ, Sagar SM, Vickers A, Blumberg JB. Should supplemental antioxidant administration be avoided during chemotherapy and radiation therapy? Journal of the National Cancer Institute. 2008;100(11):773-83. https://doi.org/10.1093/jnci/djn148
87. Mut-Salud N, Álvarez PJ, Garrido JM, Carrasco E, Aránega A, Rodríguez-Serrano F. Antioxidant intake and antitumor therapy: toward nutritional recommendations for optimal results. Oxidative Medicine and Cellular Longevity. 2016; 2016:6719534. https://doi.org/10.1155/2016/6719534
88. Yap KY, See CS, Chan A. Clinically-relevant chemotherapy interactions with complementary and alternative medicines in patients with cancer. Recent Patents on Food, Nutrition & Agriculture. 2010;2(1):12-55. https://doi.org/10.2174/2212798411002010012
89. Efferth T, Schottler U, Krishna S, Schmiedek P, Wenz F, Giordano FA. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature. Archives of Toxicology. 2017;91(4):1833-46. https://doi.org/10.1007/s00204-016-1810-z
Downloads
Published
01-04-2019
How to Cite
1.
Ghanadi K, Hasanvand A, Abbaszadeh S, Heidari-Soureshjani S, Suhan T. Phytotherapy: An anti-hepatotoxicity and hepatoprotective approach in chemotherapy. Plant Sci. Today [Internet]. 2019 Apr. 1 [cited 2024 Apr. 27];6(2):114-22. Available from: https://horizonepublishing.com/journals/index.php/PST/article/view/514
Issue
Section
Review Articles
License
Copyright and Licence details of published articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Open Access Policy
Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
