Phytochemical profiling of Mango ginger (Curcuma amada): A comprehensive review of bioactive compounds and health implications
DOI:
https://doi.org/10.14719/pst.5622Keywords:
mango ginger, phytochemical profiling, therapeutic applications, bioactive compounds, health implicationsAbstract
Mango ginger (Curcuma amada) is a rhizomatous plant of the Zingiberaceae family and has gained considerable attention because of its unique flavor and potential health benefits. The plant was widespread throughout the tropical regions of South and Southeast Asia in both wild and cultivated environments for its cure for respiratory, skin, and digestive diseases. Traditionally, mango ginger has been utilized in various ethnic medicinal practices and documented in classical medical texts such as Ayurveda, Unani, and Siddha for its therapeutic properties, including the treatment of respiratory disorders, digestive issues, and skin ailments. Phytochemical analyses have shown various bioactive compounds, including curcuminoids, terpenoids, and flavonoids, which possess various biological activities such as antioxidant, anti-inflammatory, antimicrobial, and anticancer activity. This review presents an in-depth review of the prevalence, distribution, traditional uses, and phytochemical characteristics of mango ginger while emphasizing its pharmacological potential. It also highlights the requirement for future research to uncover the molecular mechanisms involved in producing therapeutic effects to improve delivery methods, and to explore possible synergies with other bioactive compounds. Its findings provide evidence supportive of the development into a functional food, dietary supplement, and medicinal agent. This review synthesizes existing research on the phytochemical profiling of mango ginger, focusing on its bioactive compounds and applications in various industries.
Downloads
References
Jayasree M, Radhakrishnan V, Mohanan K. A scientific study on genetic variability of mango ginger (Curcuma amada Roxb.) in Kerala state of India. Cutting-edge Research in Agricultural Sciences. 2020;127.
Policegoudra RS, Aradhya MS. Accumulation of bioactive compounds during growth and development of mango ginger (Curcuma amada Roxb.) rhizomes. Journal of Agricultural and Food Chemistry. 2007;55(20):8105-11. https://doi.org/10.1021/jf0715469
Raval KG, Patel R, Panchal R, Modha K, Vadodariya G. Genetic diversity assessment in mango ginger (Curcuma amada Roxb.) germplasm based on SSR and RAPD molecular markers. Pharma Innovation. 2021;10(11):65-71.
Sasikumar B. Genetic resources of Curcuma: diversity, characterization and utilization. Plant Genetic Resources. 2005;3(2):230-51. https://doi.org/10.1079/PGR200574
Policegoudra R, Aradhya S, Singh L. Mango ginger (Curcuma amada Roxb.):a promising spice for phytochemicals and biological activities. Journal of Biosciences. 2011;36:739-48. https://doi.org/10.1007/s12038-011-9106-1
Sutar J, Monalisa K, Pati K, Chauhan VBS, Behera S. Qualitative and quantitative phytochemical analysis and antioxidant activity of Curcuma amada Roxb: an important medicinal plant. Plant Arch. 2020;20(2):193-96.
Kalpesh R, Patel R, Panchal R, Modha K. Genetic variability, correlation and path analysis in mango ginger (Curcuma amada Roxb.). Electronic Journal of Plant Breeding. 2022;13(1):235-42. https://doi.org/10.37992/2022.1301.032
Yuandani, Jantan I, Rohani AS, Sumantri IB. Immunomodulatory effects and mechanisms of Curcuma species and their bioactive compounds: a review. Frontiers in Pharmacology. 2021;12:643119. https://doi.org/10.3389/fphar.2021.643119
Bhattacharya M, Chakraborty S. Efficient in vitro regeneration of pathogen free mango ginger (Curcuma amada Roxb.) from rhizome bud explants. Research in Plant Biology. 2015;5(6).
Tamta A, Prakash O, Punetha H, Pant A. Chemical composition and in vitro antioxidant potential of essential oil and rhizome extracts of Curcuma amada Roxb. Cogent Chemistry. 2016;2(1):1168067. https://doi.org/10.1080/23312009.2016.1168067
Yadav M, Saravanan KK. Phytochemical analysis and antioxidant potential of rhizome extracts of Curcuma amada Roxb and Curcuma caesia Roxb. Journal of Drug Delivery and Therapeutics. 2019;9(5):123-26. https://doi.org/10.22270/jddt.v9i5.3609
Prakash S, Elangomathavan R, Seshadri S, Kathiravan K, Ignacimuthu S. Efficient regeneration of Curcuma amada Roxb. plantlets from rhizome and leaf sheath explants. Plant Cell Tissue and Organ Culture. 2004;78:159-65. https://doi.org/10.1023/B:TICU.0000022553.83259.29
Sharad SSS, Srivastava M, Rawat A, Shanta Mehrotra SM. Pharmacognostic evaluation of Curcuma amada Roxb. Proceedings of the National Academy of Sciences India. Section B, Biological Sciences. 2006;76(2):153-60.
Akter J, Takara K, Islam MZ, Hossain MA, Sano A, Hou DX. Isolation and structural elucidation of antifungal compounds from Curcuma amada. Asian Pacific Journal of Tropical Medicine. 2019;12(3):123-29. https://doi.org/10.4103/1995-7645.254938
Jayasankar V. Evaluating the effect of a novel Curcuma amada bioactive, 2, 4, 6-trihydroxy-3, 5-diprenyldihydrochalcone and Avocatin B on mitochondrial metabolism in acute myeloid leukemia. University of Guelph. 2020.
Abas F, Lajis NH, Shaari K, Israf DA, Stanslas J, Yusuf UK, et al. A labdane diterpene glucoside from the rhizomes of Curcuma mangga. J Nat Prod. 2005;68(7):1090-93. https://doi.org/10.1021/np0500171
Devi N, Singh P, Das A. Ethnomedicinal utilization of Zingiberaceae in the valley districts of Manipur. IOSR J Enviro Sci Toxicol Food Technol. 2014;8:21-23. https://doi.org/10.9790/2402-08242123
Rajkumari S, Sanatombi K. Nutritional value, phytochemical composition and biological activities of edible Curcuma species: a review. International Journal of Food Properties. 2017;20(sup3):s2668-s87. https://doi.org/10.1080/10942912.2017.1387556
Padalia RC, Verma RS, Sundaresan V, Chauhan A, Chanotiya CS, Yadav A. Volatile terpenoid compositions of leaf and rhizome of Curcuma amada Roxb. from northern India. Journal of Essential Oil Research. 2013;25(1):17-22. https://doi.org/10.1080/10412905.2012.747271
Hussain A, Virmani O, Popli S, Misra L, Gupta M. Dictionary of indian medicinal plants. Central Institute of Medicinal and Aromatic Plants: Lucknow. 1992;2:39.
Jatoi SA, Kikuchi A, Gilani SA, Watanabe KN. Phytochemical, pharmacological and ethnobotanical studies in mango ginger (Curcuma amada Roxb. Zingiberaceae). Phytotherapy Research: An Inter J Devot Pharmacol Toxicol Eval Nat Prod Deri. 2007;21(6):507-16. https://doi.org/10.1002/ptr.2137
Jayasree M, Radhakrishnan V, Mohanan K. Assessment of variability and selection of promising genotypes in mango ginger (Curcuma amada Roxb.) accessions from Kerala. Indian J Plant Gene Res. 2014;27(1):54-58.
Ayodele VO, Olowe OM, Afolabi CG, Kehinde IA. Identification, assessment of diseases and agronomic parameters of Curcuma amada Roxb (mango ginger). Current Plant Biology. 2018;15:51-57. https://doi.org/10.1016/j.cpb.2018.10.001
Ravindran PN, Pillai GS, Divakaran M. 28 - Other herbs and spices: mango ginger to wasabi. In: Peter KV, editor. Handbook of herbs and spices second ed: Woodhead Publishing; 2012. p. 557-82. https://doi.org/10.1533/9780857095688.557
Siddaraju M, Dharmesh SM. Inhibition of gastric H+, K+-ATPase and helicobacter pylori growth by phenolic antioxidants of Curcuma amada. Journal of Agricultural and Food Chemistry. 2007;55(18):7377-86. https://doi.org/10.1021/jf070719r
Tripura U, Sarika K. Importance of under-utilized spice crops and its cultivation practices. Advances in Horticultural Crop Management and Value Addition (first ed): Laxmi Publications Pvt Ltd; 2019. pp. 31-40.
Srinivasan M, Chandrasekhara N. Effect of mango ginger [Curcuma amada Roxb.] on triton WR-1339 induced-hyperlipidemia and plasma lipases activity in the rat. Nutrition Research. 1993;13(10):1183-90. https://doi.org/10.1016/S0271-5317(05)80742-0
Yadav O, Kumar Y, Verma P. Genetic variability, association among metric traits and path coefficient analysis in Ashwagandha (Withania somnifera). 2008.
Chatterjee R, Chattopadhyay P, Hnamte V, Chongtham T, Ray SD. Assessment of quality characteristics of mango ginger (Curcuma amada Roxb.) germplasm. International Journal of Bio-resource and Stress Management. 2012;3:380-82.
Ramachandran C, Lollett IV, Escalon E, Quirin KW, Melnick SJ. Anticancer potential and mechanism of action of mango ginger (Curcuma amada Roxb.) supercritical CO2 extract in human glioblastoma cells. Journal of Evidence Based Complementary Alternative Medicine. 2015;20(2):109-19. https://doi.org/10.1177/2156587214563731
Hossain CF, Al-Amin M, Rahman KMM, Sarker A, Alam MM, Chowdhury MH, et al. Analgesic principle from Curcuma amada. Journal of Ethnopharmacology. 2015;163:273-77. https://doi.org/10.1016/j.jep.2015.01.018
Gupta RK, Himanshu Gaur HG, Pati JK, Archana Pandey AP. Evaluation of antioxidant potential of different extracts of mango ginger (Curcuma amada Roxb.) rhizome. 2015.
Rao AS, Rajanikanth B, Seshadri R. Volatile aroma components of Curcuma amada Roxb. Journal of Agricultural and Food Chemistry. 1989;37(3):740-43. https://doi.org/10.1021/jf00087a036
Policegoudra RS, Chandrashekhar RH, Aradhya SM, Singh L. Cytotoxicity, platelet aggregation inhibitory and antioxidant activity of Curcuma amada Roxb. Extracts Genus. 2011;49(2):162-68.
Sahoo S, Jyotirmayee B, Nayak S, Samal HB, Mahalik G. Review on phytopharmacological activity of Curcuma amada Roxb (Mango ginger). Journal of Defence Life Science. 2023;8(4):351-62.
Saipriya V, Abirami A, Krishnan A, Siddhuraju P. Studies on total phenolic content and antioxidant activities of aqueous acetone and methanolic extracts from raw and boiled rhizomes of Maranta arudinaceae L. and Curcuma amada Roxb. International Journal of Food Science and Nutrition. 2017;2(4):88-94.
Chen Y, Shukurova MK, Asikin Y, Kusano M, Watanabe KN. Characterization of volatile organic compounds in mango ginger (Curcuma amada Roxb.) from Myanmar. Metabolites. 2020;11(1):21. https://doi.org/10.3390/metabo11010021
Mahadevi R, Salmen SH, Alfarraj S, Wainwright M, Kavitha R. Screening and characterization of phytochemical content of methanolic extract of rhizome of Curcuma amada and their antibacterial activity against MRSA. Applied Nanoscience. 2021;1-11. https://doi.org/10.1007/s13204-021-02061-6
Annapurna A, Abhirami D, Umesh T. Comparative study of phytochemicals and bioactivities of the leaf extracts of Curcuma amada and Curcuma karnatakensis. South African Journal of Botany. 2021;142:441-50. https://doi.org/10.1016/j.sajb.2021.06.032
Narayanankutty A, Sasidharan A, Job JT, Rajagopal R, Alfarhan A, Kim YO, et al. Mango ginger (Curcuma amada Roxb.) rhizome essential oils as source of environmental friendly biocides: comparison of the chemical composition, antibacterial, insecticidal and larvicidal properties of essential oils extracted by different methods. Environmental Research. 2021;202:111718. https://doi.org/10.1016/j.envres.2021.111718
Singh S, Kumar JK, Saikia D, Shanker K, Thakur JP, Negi AS, et al. A bioactive labdane diterpenoid from Curcuma amada and its semisynthetic analogues as antitubercular agents. European Journal of Medicinal Chemistry. 2010;45(9):4379-82. https://doi.org/10.1016/j.ejmech.2010.06.006
Panwar NS, Singh M, Limaye R, Puri P. Antioxidant and anti-inflammatory studies of leaf of Ricinus communis and rhizome of Curcuma amada for topical application. International Journal of Innovative Science and Research Technology. 2023;8:1.
Lenka J, Khuntia S, Kar B, Sahoo S. Metabolic profile, bioactivities and variations in chemical constituents of essential oils of twenty mango ginger (Curcuma amada) accessions. Journal of Applied Biology and Biotechnology. 2023;11(6):147-57.https://doi.org/10.7324/JABB.2023.129372
Chandarana H, Baluja S, Chanda S. Comparison of antibacterial activities of selected species of Zingiberaceae family and some synthetic compounds. Turkish Journal of Biology. 2005;29(2):83-97.
Policegoudra R, Rehna K, Jaganmohan Rao L, Aradhya S. Antimicrobial, antioxidant, cytotoxicity and platelet aggregation inhibitory activity of a novel molecule isolated and characterized from mango ginger (Curcuma amada Roxb.) rhizome. Journal of Biosciences. 2010;35:231-40. https://doi.org/10.1007/s12038-010-0027-1
Kashyap NK, Deepak J, Bhardwaj AK, Hait M, Pal D. In-vitro antibacterial and antifungal activity of Curcuma amada Roxb against human pathogens. Trends in Sciences. 2022;19(22):4839.https://doi.org/10.48048/tis.2022.4839
Rao MR, Reddy IB, Gopal SR, Bhaskar D, Ramana T. A comparative study of antimicrobial activity of Curcuma amada and Alpinia galanga of Zingiberaceae family. Asian Journal of Chemistry. 2008;20(7):5293.
Prasath HC, Divyapriya S, Kumar VDR. Physicochemical, formulation and evaluation of antifungal herbal soap using Curcuma amada roxburgh and Prunus dulcis. Asian Journal of Pharmaceutical and Clinical Research. 2023.
Aggarwal BB, Sundaram C, Malani N, Ichikawa H. Curcumin: the indian solid gold. The molecular targets and therapeutic uses of curcumin in health and disease. In: Advances in Experimental Medicine and Biology. 2007;1-75. https://doi.org/10.1007/978-0-387-46401-5_1
Nag A, Banerjee R, Goswami P, Bandyopadhyay M, Mukherjee A. Antioxidant and antigenotoxic properties of Alpinia galanga, Curcuma amada and Curcuma caesia. Asian Pacific Journal of Tropical Biomedicine. 2021;11(8). https://doi.org/10.4103/2221-1691.319571
Pachauri S, Mukherjee SK. Effect of Curcuma longa and Curcuma amada on the cholesterol levels in experimental hyper cholesterolemia of rabbits. J Res Indian Med. 1970;5:27-31.
Palpu P, Rao CV, Rawat AKS, Ojha SK, Reddy GD. Anti-allergic herbal formulation. Google Patents; 2008.
Mujumdar A, Naik D, Dandge C, Puntambekar H. Antiinflammatory activity of Curcuma amada Roxb in albino rats. Indian Journal of Pharmacology. 2000;32(6):375-77.
Misra S, Dixit V. Pharmaceutical studies on starches of some Zingiberaceous rhizomes. Indian Journal of Pharmaceutical Sciences. 1983;45(5):216-20.
Tabtipwon P, Temsiririrkkul R, Thongpraditchote S, Buranaphalin S, Bongcheewin B, Kongsawadworakul P. Anti-inflammatory activity of Curcuma cf. amada Roxb.Wan en Lueang. Pharmaceutical Sciences Asia. 2020;47(2). https://doi.org/10.4103/2221-1691.319571
Ravindran P, Babu KN, Sivaraman K. Turmeric: the genus Curcuma. CRC press; 2007. https://doi.org/10.1201/9781420006322
Devi ST, Sanatombi K. Bioactive compounds and biological activities of Curcuma species. In: Bioactive compounds in the storage organs of plants. Springer; 2024. p. 337-93.
Jabsuwan A, Sukrong S, Swasdison S, Towiwat P. Antinociceptive and anti-inflammatory effects of the ethanolic extract of Curcuma aff. amada. Chiang Mai J Sci. 2015;44:912-28.
Donipati P, Sreeramulu SH, Donipati PJ, Yugandhar N. In vitro anticancer activity of Curcuma amada against human breast cancer cell line mcf-7. NeuroQuantology. 2022;20(20):2875.
Ramachandran C, Portalatin GM, Prado AM, Quirin KW, Escalon E, Melnick SJ. In vivo antitumor effect of supercritical CO2 extract of mango ginger (Curcuma amada Roxb) in U-87MG human glioblastoma nude mice xenografts. Journal of Evidence-Based Complementary and Alternative Medicine. 2017;22(2):260-67. https://doi.org/10.1177/2156587216659390
Mitra D, Sarkar R, Ghosh D. Antidiabetic and antioxidative properties of the hydro-methanolic extract (60:40) of rhizomes of Curcuma amada Roxb. (Zingiberaceae) in streptozotocin-induced diabetic male albino rat: a dose-dependent study through biochemical and genomic approaches. Journal of Complementary and Integrative Medicine. 2019;16(4):20170182. https://doi.org/10.1515/jcim-2017-0182
Syiem D, Monsang SW, Sharma R. Hypoglycemic and anti-hyperglycemic activity of Curcuma amada Roxb. in normal and alloxan-induced diabetic mice. Journal of Pharmacologyonline. 2010;3:364-72.
Bhawna S, Kumar SU. Hepatoprotective activity of some indigenous plants. Int J Pharm Tech Res. 2009;4:1330-34.
Mishra J, Bhardwaj A, Misra K. Curcuma sp.: the nature's souvenir for high-altitude illness. In: Management of High Altitude Pathophysiology. Elsevier. 2018. p. 153-69. https://doi.org/10.1016/B978-0-12-813999-8.00008-2
Jena S, Ray A, Rath D, Sahoo A, Singh S, Nasim N, et al. Curcuma angustifolia ameliorates carbon tetrachloride-induced hepatotoxicity in HepG2 cells and swiss albino rats. Asian Pacific Journal of Tropical Medicine. 2019;12(9):416-24. https://doi.org/10.4103/1995-7645.267585
Singh R. Evaluation of essential oils of selected spices as food preservatives [Thesis]. 2019.
Caccamo D, Pisani L, Mazzocchetti P, Ientile R, Calabresi P, Pisani F, et al. Neuroprotection as a potential therapeutic perspective in neurodegenerative diseases: focus on antiepileptic drugs. Neurochemical Research. 2016;41:340-52. https://doi.org/10.1007/s11064-015-1809-5
Ali MC, Munni YA, Das R, Akter N, Das K, Mitra S, et al. In silico chemical profiling and identification of neuromodulators from Curcuma amada targeting acetylcholinesterase. Network Modeling Analysis in Health Informatics and Bioinformatics. 2021;10:1-16. https://doi.org/10.1007/s13721-021-00334-2
Prema D, Kamaraj M, Achiraman S, Udayakumar R. In vitro antioxidant and cytotoxicity studies of Curcuma amada Roxb.(mango ginger). International Journal of Science and Research. 2014;4(4):01-06.
Hait M, Deepak J. Physicochemical and phytochemical exploration on non-aerial part of Curcuma amada. Journal of Pharmacognosy and Phytochemistry. 2018;7(6):1306-09.
Shankaracharya N. Mango ginger. Indian Cocoa, Arecanut and Spices Journal. 1982;5(4):78-80.
Behera KK. Ethnomedicinal plants used by the tribals of similipal bioreserve, Orissa, India: a pilot study. Ethnobotanical Leaflets. 2006;2006(1):17.
Gupta A, Gupta M, Kumar S. Simultaneous determination of curcuminoids in Curcuma samples using high performance thin layer chromatography. Journal of Liquid Chromatography and Related Technologies. 1999;22(10):1561-69. https://doi.org/10.1081/JLC-100101751
Nadkarni K. Indian materia medica. 3rd ed. Popular Book Depot. Bombay: Dhootapapeshwar Prakashan Ltd. Panvel. 1954;1:1229-32.
Kapoor L. CRC Handbook of ayurvedic medicinal plants. CRC Press; 2018. https://doi.org/10.1201/9781351070997
Kirthikar KR, Basu BD. Indian medicinal plants vol_2. In: Blatter E, Caius JF, Mhaskar KS, editors. Archeological Survey, Medicinal plants, Herbs, Plant, Analysis. Archaeological Survey of India
Central Archaeological Library, New Delhi; 1934 [cited 05 nov 2017]:1-798. Available from: http://asi.nic.in/asi_books/2047.pdf
Policegoudra R, Aradhya S. Biochemical changes and antioxidant activity of mango ginger (Curcuma amada Roxb.) rhizomes during postharvest storage at different temperatures. Postharvest Biology and Technology. 2007;46(2):189-94. https://doi.org/10.1016/j.postharvbio.2007.04.012
Srivastava A, Srivastava S, Shah N. Constituents of the rhizome essential oil of Curcuma amada Roxb. from India. Journal of Essential Oil Research. 2001;13(1):63-64. https://doi.org/10.1080/10412905.2001.9699608
Singh G, Sing OP, Perotti ME, Catalan CAN. Curcuma amada Roxb.chemical composition of rhizome oil. 2003.
Choudhary L, Rasool MA, Pounikar Y, Ahirwar DK, Jain R, Sahu S. In silico investigation of various phytoconstituents present in mango ginger (Curcuma amada Roxb.) as antibacterial agents. African Journal of Biological Sciences. 2024;6(8):450-59.
Gholap AS, Bandyopadhyay C. Characterization of mango-like aroma in Curcuma amada Roxb. Journal of Agricultural and Food Chemistry. 1984;32(1):57-59. https://doi.org/10.1021/jf00121a015
Policegoudra R, Divakar S, Aradhya S. Identification of difurocumenonol, a new antimicrobial compound from mango ginger (Curcuma amada Roxb.) rhizome. Journal of Applied Microbiology. 2007;102(6):1594-602. https://doi.org/10.1111/j.1365-2672.2006.03186.x
Policegoudra R, Abiraj K, Gowda DC, Aradhya S. Isolation and characterization of antioxidant and antibacterial compound from mango ginger (Curcuma amada Roxb.) rhizome. Journal of Chromatography B. 2007;852(1-2):40-48. https://doi.org/10.1016/j.jchromb.2006.12.036
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 P D Barman, V Rajasree, M Mohanalakshmi, R Renuka, P Meenakshi
This work is licensed under a Creative Commons Attribution 4.0 International License.
Copyright and Licence details of published articles
Authors who publish with this journal agree to the following terms:
- Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
- Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
Open Access Policy
Plant Science Today is an open access journal. There is no registration required to read any article. All published articles are distributed under the terms of the Creative Commons Attribution License (CC Attribution 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited (https://creativecommons.org/licenses/by/4.0/). Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).
